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A mucosa-mimetic material for the mucoadhesion testing of thermogelling semi-solids

da Silva, J. B., Khutoryanskiy, V. V., Bruschi, M. L. and Cook, M. T. (2017) A mucosa-mimetic material for the mucoadhesion testing of thermogelling semi-solids. International Journal of Pharmaceutics, 528 (1-2). pp. 586-594. ISSN 0378-5173

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To link to this item DOI: 10.1016/j.ijpharm.2017.06.025

Abstract/Summary

Mucosa-mimetic materials are synthetic substrates which aim to replace animal tissue in mucoadhesion experiments. One potential mucosa-mimetic material is a hydrogel comprised of N-acryloyl-d-glucosamine and 2-hydroxyethylmethacrylate, which has been investigated as a surrogate for animal mucosae in the mucoadhesion testing of tablets and solution formulations. This study aims to investigate the efficacy of this mucosa-mimetic material in the testing of thermogelling semi-solid formulations, which transition from solution to gel upon warming. Two methods for assessing mucoadhesion have been used; tensile testing and a flow-through system, which allow for investigation under dramatically different conditions. It was found that the mucosa-mimetic material was a good surrogate for buccal mucosa using both testing methods. This material may be used to replace animal tissue in these experiments, potentially reducing the number of laboratory animals used in studies of this type.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
ID Code:71723
Publisher:Elsevier

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