Sequence-selective assembly of tweezer-molecules on linear templates enables frameshift-reading of sequence information
Zhu, Z., Cardin, C. J., Gan, Y. and Colquhoun, H. M. (2010) Sequence-selective assembly of tweezer-molecules on linear templates enables frameshift-reading of sequence information. Nature Chemistry, 2 (8). pp. 653-660. ISSN 1755-4330
To link to this article DOI: 10.1038/NCHEM.699
Monomer-sequence information in synthetic copolyimides can be recognised by tweezer-type molecules binding to adjacent triplet-sequences on the polymer chains. In the present paper different tweezer-molecules are found to have different sequence-selectivities, as demonstrated in solution by 1H NMR spectroscopy and in the solid state by single crystal X-ray analyses of tweezer-complexes with linear and macrocyclic oligo-imides. This work provides clear-cut confirmation of polyimide chain-folding and adjacent-tweezer-binding. It also reveals a new and entirely unexpected mechanism for sequence-recognition which, by analogy with a related process in biomolecular information processing, may be termed "frameshift-reading". The ability of one particular tweezer-molecule to detect, with exceptionally high sensitivity, long-range sequence-information in chain-folding aromatic copolyimides, is readily explained by this novel process.