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Outcome of cell suspension allografts in a patient with Huntington’s disease

Maxan, A., Mason, S., Saint-Pierre, M., Smith, E., Ho, A., Harrower, T., Watts, C., Tai, Y., Pavese, N., Savage, J. C., Tremblay, M.-E., Gould, P., Rosser, A. E., Dunnett, S. B., Piccini, P., Barker, R. A. and Cicchetti, F. (2018) Outcome of cell suspension allografts in a patient with Huntington’s disease. Annals of Neurology, 84 (6). pp. 950-956. ISSN 1531-8249

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To link to this item DOI: 10.1002/ana.25354

Abstract/Summary

For patients with incurable neurodegenerative disorders such as Huntington’s (HD) and Parkinson’s disease, cell transplantation has been explored as a potential treatment option. Here, we present the first clinicopathological study of a patient with HD in receipt of cell-suspension striatal allografts who took part in the NEST-UK multicenter clinical transplantation trial. Using various immunohistochemical techniques, we found a discrepancy in the survival of grafted projection neurons with respect to grafted interneurons as well as major ongoing inflammatory and immune responses to the grafted tissue with evidence of mutant huntingtin aggregates within the transplant area. Our results indicate that grafts can survive more than a decade posttransplantation, but show compromised survival with inflammation and mutant protein being observed within the transplant site.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Centre for Integrative Neuroscience and Neurodynamics (CINN)
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Neuroscience
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Psychopathology and Affective Neuroscience
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Nutrition and Health
ID Code:80140
Publisher:Wiley

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