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Sensory over-responsivity: parent report, direct assessment measures, and neural architecture

Tavassoli, T., Brandes-Aitken, A., Chu, R., Porter, L., Schoen, S., Miller, L. J., Gerdes, M. R., Owen, J., Mukherjee, P. and Marco, E. J. (2019) Sensory over-responsivity: parent report, direct assessment measures, and neural architecture. Molecular Autism, 10 (4). ISSN 2040-2392

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To link to this item DOI: 10.1186/s13229-019-0255-7

Abstract/Summary

BACKGROUND: Sensory processing difficulties are common across neurodevelopmental disorders. Thus, reliable measures are needed to understand the biological underpinnings of these differences. This study aimed to define a scoring methodology specific to auditory (AOR) and tactile (TOR) over-responsivity. Second, in a pilot cohort using MRI Diffusion Tensor Imaging, we performed a proof of concept study of whether children with AOR showed measurable differences in their white matter integrity. METHODS: This study included children with AOR and TOR from a mixed neurodevelopmental disorder cohort including autism and sensory processing dysfunction (n = 176) as well as neurotypical children (n = 128). We established cohorts based on sensory over-responsivity using parent report (Short Sensory Profile (SSP)) and direct assessment (Sensory Processing-Three Dimensions: Assessment (SP-3D:A)) measures. With a subset of the children (n = 39), group comparisons, based on AOR phenotype, were conducted comparing the white matter fractional anisotropy in 23 regions of interest. RESULTS: Using direct assessment, 31% of the children with neurodevelopmental disorders had AOR and 27% had TOR. The inter-test agreement between SSP and SP-3D:A for AOR was 65% and TOR was 50%. Children with AOR had three white matter tracts showing decreased fractional anisotropy relative to children without AOR. CONCLUSIONS: This study identified cut-off scores for AOR and TOR using the SSP parent report and SP-3D:A observation. A combination of questionnaire and direct observation measures should be used in clinical and research settings. The SSP parent report and SP-3D:A direct observation ratings overlapped moderately for sensory related behaviors. Based on these preliminary structural neuroimaging results, we suggest a putative neural network may contribute to AOR.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Centre for Integrative Neuroscience and Neurodynamics (CINN)
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
ID Code:82747
Uncontrolled Keywords:Assessment, Autism, Sensory Processing Disorder, Sensory Over-responsivity, Neurodevelopmental Disorder, Diffusion Tensor Imaging
Publisher:BMC

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