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Secretome of mesenchymal stem cells and its impact on Chronic Obstructive Pulmonary Disease

Ridzuan, R., Widera, D. and Yahaya, B. H. (2019) Secretome of mesenchymal stem cells and its impact on Chronic Obstructive Pulmonary Disease. In: Pham, P. V. (ed.) Stem Cell Transplantation for Autoimmune Diseases and Inflammation. Stem Cells in Clinical Applications. Springer, pp. 139-157. ISBN 978-3-030-23420-1

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To link to this item DOI: 10.1007/978-3-030-23421-8_8

Abstract/Summary

Chronic obstructive pulmonary disease (COPD) is characterized by irreversible loss of lung function that stem from two mechanisms, inflammation and senescence. Crosstalk between these two mechanisms accelerate the development of COPD, thus targeting these two pathways may offer benefits in the treatment of COPD. Growing amount of evidence have shown that mesenchymal stem cells as a promising candidate for the treatment of COPD. Over the years, many studies conducted to decipher the therapeutic effect of MSC in COPD and the mechanisms involve, in the hope of utilizing these cells as new therapeutic strategy for COPD. However, the cell-based therapy by using the MSC presented with many obstacles including low engraftment at the site of injury, the risk of microvascular occlusion, unwanted differentiation, and also the risk of malignant transformation. Recently, recently researchers begin to look at the possibility of using MSC derived extracellular vesicles as an alternative to MSC. Here we review the effect of MSC and MSC derived EV in modulating inflammation, and senescence in COPD. We also review current treatment and the side effect in COPD, and senolytic drugs, a new therapeutic strategy targeting the senescent cells.

Item Type:Book or Report Section
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
ID Code:85665
Publisher:Springer

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