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Ca2+ waves coordinate purinergic receptor–evoked integrin activation and polarization

Bye, A. P., Gibbins, J. M. and Mahaut-Smith, M. P. (2020) Ca2+ waves coordinate purinergic receptor–evoked integrin activation and polarization. Science Signaling, 13 (615). eaav7354. ISSN 1937-9145

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To link to this item DOI: 10.1126/scisignal.aav7354

Abstract/Summary

The integrin GPIIb/IIIa is highly abundant on the surface of platelets and can be activated by intracellular Ca2+ signaling in an “inside-out” manner to bind to the adhesive ligand fibrinogen. Bye et al. imaged intracellular Ca2+ signaling and fibrinogen binding events in primary rat megakaryocytes activated through the ADP-stimulated receptors P2Y1 and P2Y12. The authors found that signaling by both receptors was required for full integrin activation, which depended on P2Y1-stimulated Ca2+ signaling and P2Y12-stimulated activation of the kinase PI3K. In addition, fibrinogen binding became polarized in these cells in a manner dependent on the direction of ADP-stimulated Ca2+ waves.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:88548
Uncontrolled Keywords:Platelet, Megakaryocyte, Integrin, Calcium, Ca2+, Fibrinogen, GPCR, Synergy, P2Y1, P2Y12, ADP, Adenosine Diphosphate
Publisher:AAAS

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