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Human skin explant model for the investigation of topical therapeutics

Neil, J. E., Brown, M. B. and Williams, A. C. (2020) Human skin explant model for the investigation of topical therapeutics. Scientific Reports, 10 (1). 21192. ISSN 2045-2322

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To link to this item DOI: 10.1038/s41598-020-78292-4

Abstract/Summary

The development of in vitro and ex vivo models to mimic human illness is important not only for scientific understanding and investigating therapeutic approaches but also to mitigate animal testing and bridge the inter-species translational gap. While in vitro models can facilitate high-throughput and cost-efficient evaluation of novel therapeutics, more complex ex vivo systems can better predict both desirable and adverse in vivo effects. Here we describe an ex vivo cultured human skin explant model in which we have characterized pathological tissue integrity, barrier function and metabolic stability over time. Our findings suggest that human skin can be successfully cultured for pharmacodynamic use up to and beyond 9 days without any adverse physiological consequence.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
ID Code:94772
Publisher:Nature Publishing Group

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