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Nucleolin is regulated both at the level of transcription and translation

Bicknell, K., Brooks, G., Kaiser, P., Chen, H. Y., Dove, B. K. and Hiscox, J. A. (2005) Nucleolin is regulated both at the level of transcription and translation. Biochemical and Biophysical Research Communications, 332 (3). pp. 817-822. ISSN 0006-291X

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To link to this item DOI: 10.1016/j.bbrc.2005.05.022


Nucleolin is a multi-functional protein that is located to the nucleolus. In tissue Culture cells, the stability of nucleolin is related to the proliferation status of the cell. During development, rat cardiomyocytes proliferate actively with increases in the mass of the heart being due to both hyperplasia and hypertrophy. The timing of this shift in the phenotype of the myocyte from one capable of undergoing hyperplasia to one that can grow only by hypertrophy occurs within 4 days of post-natal development. Thus, cardiomyocytes are an ideal model system in which to study the regulation of nucleolin during growth in vivo. Using Western blot and quantitative RT-PCR (TaqMan) we found that the amount of nucleolin is regulated both at the level of transcription and translation during the development of the cardiomyocyte. However, in cells which had exited the cell cycle and were subsequently given a hypertrophic stimulus, nucleolin was regulated post-transcriptionally. (c) 2005 Elsevier Inc. All rights reserved.

Item Type:Article
Divisions:Life Sciences > School of Biological Sciences
Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:10281
Uncontrolled Keywords:developrnent, cardiomyocyte, heart, hyperplasia, hypertrophy, nucleolin, nucleolus, rat, TaqMan, MESSENGER-RNA, INHIBITION, HYPERTROPHY, EXPRESSION, GROWTH, CELLS, REPLICATION, STABILITY, INFECTION, PROTEINS

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