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Reprogrammed CD8+ T-lymphocytes isolated from bone marrow have anticancer potential in lung cancer

Skurikhin, E. G., Pershina, O. ORCID:, Ermakova, N., Pakhomova, A. ORCID:, Widera, D. ORCID:, Zhukova, M. ORCID:, Pan, E. ORCID:, Sandrikina, L., Kogai, L., Kushlinskii, N., Morozov, S. G., Kubatiev, A. and Dygai, A. (2022) Reprogrammed CD8+ T-lymphocytes isolated from bone marrow have anticancer potential in lung cancer. Biomedicines, 10 (6). 1450. ISSN 2227-9059

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To link to this item DOI: 10.3390/biomedicines10061450


CD8+ T-lymphocytes play a key role in antitumor immune response. Patients with lung cancer often suffer from T-lymphocyte dysfunction and low T-cell counts. The exhaustion of effector T-lymphocytes largely limits the effectiveness of therapy. In this study, reprogrammed T-lymphocytes used MEK inhibitors and PD-1 blockers to increase their antitumor activity. Antitumor effects of reprogrammed T-lymphocytes were shown in vitro and in vivo in the Lewis lung carcinoma model. The population of T- lymphocytes with persistent expression of CCR7 was formed as a result of reprogramming. Reprogrammed T-lymphocytes were resistant to apoptosis and characterized by high cytotoxicity against Lewis lung carcinoma (LLC) cells in vitro. Administration of reprogrammed T-lymphocytes to C57BL/6 mice with LLC reduced the number of lung metastases. The antitumor effect resulted from the elimination of tumor cells and cancer stem cells, and the effect of therapy on cytotoxic T-lymphocyte counts. Thus, reprogramming of T-lymphocytes using MEK inhibitors is a promising approach for targeted therapy of lung cancer.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group
ID Code:106579


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