2023

Kramer, H.B.R. and Allman, S. A. (2023) Sugar coating autophagy: exploring the links between the inhibition of NGLY1 (N-glycanase 1) and autophagy induction. Autophagy Reports, 2 (1). 2166324. ISSN 2769-4127 doi: https://doi.org/10.1080/27694127.2023.2166324

Mitry, M. M. A., Greco, F. and Osborn, H. M. I. (2023) In vivo applications of bioorthogonal reactions- chemistry and targeting mechanisms. Chemistry - A European Journal. ISSN 0947-6539 (In Press)

2022

Albadawi, D. A. I., Ravishankar, D., Vallance, T. M., Patel, K., Osborn, H. M. I. and Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517 (2022) Impacts of commonly used edible plants on the modulation of platelet function. International Journal of Molecular Sciences, 23 (2). 605. ISSN 1422-0067 doi: https://doi.org/10.3390/ijms23020605

Allman, S., Cordy, J., Hall, J., Kleanthous, V. and Lander, L. (2022) Exploring the perception of additional information content in 360° 3D VR video for teaching and learning. Virtual Worlds, 1 (1). pp. 1-17. ISSN 2813-2084 doi: https://doi.org/10.3390/virtualworlds1010001

Baker, Y. R., Thorpe, C., Chen, J., Poller, L. M., Cox, L., Kumar, P., Lim, W. F., Lie, L., McClorey, G., Epple, S., Singleton, D., McDonough, M. A., Hardwick, J. S., Christensen, K. E., Wood, M. J. A., Hall, J. P., El-Sagheer, A. H. and Brown, T. (2022) An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides. Nature Communications, 13. pp. 1-13. ISSN 2041-1723 doi: https://doi.org/10.1038/s41467-022-31636-2

Cheeseman, J., Badia, C., Thomson, R. I., Kuhnle, G. ORCID: https://orcid.org/0000-0002-8081-8931, Gardner, R. A., Spencer, D. I. R. and Osborn, H. M. I. (2022) Quantitative standards of 4-O acetyl and 9-O acetyl N-acetyl neuraminic acid for the analysis of plasma and serum. ChemBioChem, 23 (5). e202100662. ISSN 1439-7633 doi: https://doi.org/10.1002/cbic.202100662

Dalla Pozza, M., Abdullrahman, A., Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995, Gasser, G. and Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378 (2022) Three’s a crowd – stabilisation, structure, and applications of DNA triplexes. Chemical Science (35). pp. 10193-10215. ISSN 2041-6539 doi: https://doi.org/10.1039/d2sc01793h

Hutchins, M., Bovill, R. A., Stephens, P. J., Brazier, J. A. and Osborn, H. M. I. (2022) Glycosides of nadifloxacin—synthesis and antibacterial activities against methicillin-resistant Staphylococcus aureus. Molecules, 27 (5). 1504. ISSN 1420-3049 doi: https://doi.org/10.3390/molecules27051504

Khater, M., Brazier, J., Greco, F. and Osborn, H. (2022) Anticancer evaluation of new organometallic ruthenium(II) flavone complexes. Medicinal Chemistry. ISSN 2632-8682 doi: https://doi.org/10.1039/D2MD00304J

Khater, M., Watson, K. A. ORCID: https://orcid.org/0000-0002-9987-8539, Boateng, S. Y., Greco, F. and Osborn, H. M. I. (2022) Halogenated flavonoid derivatives display antiangiogenic activity. Molecules, 27 (15). 4757. ISSN 1420-3049 doi: https://doi.org/10.3390/molecules27154757

McQuaid, K. T., Takahashi, S., Baumgaertner, L., Cardin, D. J., Paterson, N. G., Hall, J. P., Sugimoto, N. and Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 (2022) Ruthenium polypyridyl complex bound to a unimolecular chair-form G-quadruplex. Journal of the American Chemical Society, 144 (13). pp. 5956-5964. ISSN 0002-7863 doi: https://doi.org/10.1021/jacs.2c00178

Ridzuan, N., Widera, D. ORCID: https://orcid.org/0000-0003-1686-130X and Yahaya, B. H. (2022) Isolation and characterization of extracellular vesicles derived from human umbilical cord mesenchymal stem cells. In: Kannan, N. and Beer, P. (eds.) Stem Cell Assays. Methods in Molecular Biology, 2429 (2429). Springer, pp. 271-280. ISBN 9781071619797 doi: https://doi.org/10.1007/978-1-0716-1979-7_18 (ISSN 1940-6029)

Skurikhin, E. G., Pershina, O. ORCID: https://orcid.org/0000-0002-0468-0272, Ermakova, N., Pakhomova, A. ORCID: https://orcid.org/0000-0003-0725-1323, Widera, D. ORCID: https://orcid.org/0000-0003-1686-130X, Zhukova, M. ORCID: https://orcid.org/0000-0002-8146-2279, Pan, E. ORCID: https://orcid.org/0000-0002-2163-7647, Sandrikina, L., Kogai, L., Kushlinskii, N., Morozov, S. G., Kubatiev, A. and Dygai, A. (2022) Reprogrammed CD8+ T-lymphocytes isolated from bone marrow have anticancer potential in lung cancer. Biomedicines, 10 (6). 1450. ISSN 2227-9059 doi: https://doi.org/10.3390/biomedicines10061450

Trinh, D. N., Radlinskaite, M., Cheeseman, J., Kuhnle, G. ORCID: https://orcid.org/0000-0002-8081-8931, Osborn, H. M. I., Meleady, P., Spencer, D. I. R. and Monopoli, M. P. (2022) Biomolecular corona stability in association with plasma cholesterol level. Nanomaterials, 12 (15). 2661. ISSN 2079-4991 doi: https://doi.org/10.3390/nano12152661

2021

Babra, T., Warriner, C., Bazin, N., Hayes, W. and Greenland, B. (2021) A fluoride degradable crosslinker for debond-on-demand polyurethane based crosslinked adhesives. Materials Today Communications, 26. 101777. ISSN 2352-4928 doi: https://doi.org/10.1016/j.mtcomm.2020.101777

Cheeseman, J., Kuhnle, G. ORCID: https://orcid.org/0000-0002-8081-8931, Stafford, G., Gardner, R., Spencer, D. and Osborn, H. (2021) Sialic acid as a potential biomarker for cardiovascular disease, diabetes and cancer. Biomarkers in Medicine, 15 (11). pp. 911-928. ISSN 1752-0363 doi: https://doi.org/10.2217/bmm-2020-0776

Cheeseman, J., Kuhnle, G. ORCID: https://orcid.org/0000-0002-8081-8931, Spencer, D. I.R. and Osborn, H. (2021) Assays for the identification and quantification of sialic acids: challenges, opportunities and future perspectives. Bioorganic & Medicinal Chemistry, 30. 115882. ISSN 0968-0896 doi: https://doi.org/10.1016/j.bmc.2020.115882

Dawood, D. H., Srour, A. M., Saleh, D. O., Huff, K. J., Greco, F. and Osborn, H. M. I. (2021) New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents. RSC Advances, 11. pp. 29441-29452. ISSN 2046-2069 doi: https://doi.org/10.1039/D1RA04758B

Manzoni, C. and Ferrari, R. (2021) Mendelian and sporadic FTD: disease risk and avenues from genetics to disease pathways through in silico modelling. In: Ghetti, B., Buratti, E., Boeve, B. and Rademakers, R. (eds.) Frontotemporal Dementias. Advances in Experimental Medicine and Biology, 1281. Springer, pp. 283-296. ISBN 9783030511395 doi: https://doi.org/10.1007/978-3-030-51140-1_17

2020

Baptista, F. R., Devereux, S. J., Gurung, S. P., Hall, J. P., Sazanovich, I. V., Towrie, M., Cardin, C. J., Brazier, J. A., Kelly, J. M. and Quinn, S. J. (2020) The influence of loops on the binding of the [Ru(phen)2dppz]2+ light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy. Chemical Communications, 56 (67). pp. 9703-9706. ISSN 1359-7345 doi: https://doi.org/10.1039/D0CC03702H

Council, C. E., Kilpin, K. J., Gusthart, J. S., Allman, S. A., Linclau, B. and Lee, S. S. (2020) Enzymatic glycosylation involving fluorinated carbohydrates. Organic & Biomolecular Chemistry, 18 (18). pp. 3423-3451. ISSN 1477-0520 doi: https://doi.org/10.1039/D0OB00436G

Hall, J. P. and Allman, S. A. (2020) Blending virtual reality with traditional approaches to encourage engagement with core chemistry concepts relevant to an undergraduate pharmacy curriculum. Pharmacy Education, 20 (1). pp. 365-374. ISSN 1477-2701 doi: https://doi.org/10.46542/pe.2020.201.365374

Khater, M., Greco, F. and Osborn, H. M. I. (2020) Antiangiogenic activity of flavonoids: a systematic review and meta-analysis. Molecules, 25 (20). 4712. ISSN 1420-3049 doi: https://doi.org/10.3390/molecules25204712

Natfji, A. A., Nikitin, D. O., Semina, I. I., Moustafine, R. I., Khutoryanskiy, V. V., Lin, H., Stephens, G. J., Watson, K. A., Osborn, H. M. I. and Greco, F. (2020) Conjugation of haloperidol to PEG allows peripheral localisation of haloperidol and eliminates CNS extrapyramidal effects. Journal of Controlled Release, 322. pp. 227-235. ISSN 0168-3659 doi: https://doi.org/10.1016/j.jconrel.2020.02.037

Tomkins, J. E. (2020) Defining the Proximal Interactome of Death-Associated Protein Kinase 1. PhD thesis, University of Reading. doi: https://doi.org/10.48683/1926.00104248

2019

Conlon, P. F., Eguaogie, O., Wilson, J., Sweet, J. S. T., Steinhögl, J., Englert, K., Hancox, O. G. A., Law, C. J., Allman, S. A., Tucker, J. H. R., Hall, J. P. and Vyle, J. S. (2019) Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography. Chemical Science, 10 (47). pp. 10948-10957. ISSN 1478-6524 doi: https://doi.org/10.1039/C9SC04098F

Howse, G. L., Bovill, R. A., Stephens, P. J. and Osborn, H. M. I. (2019) Synthesis and antibacterial profiles of targeted triclosan derivatives. European Journal of Medicinal Chemistry, 162. pp. 51-58. ISSN 0223-5234 doi: https://doi.org/10.1016/j.ejmech.2018.10.053

Khater, M., Ravishankar, D., Greco, F. and Osborn, H. (2019) Metal complexes of flavonoids: their synthesis, characterization, and enhanced anti-oxidant and anti-cancer activities. Future Medicinal Chemistry, 11 (21). ISSN 1756-8927 doi: https://doi.org/10.4155/fmc-2019-0237

McQuaid, K., Hall, J. P., Baumgaertner, L., Cardin, D. J. and Cardin, C. J. (2019) Three thymine/adenine binding modes of the ruthenium complex Λ-[Ru (TAP)2(dppz)]2+ to the G-quadruplex forming sequence d(TAGGGTT) shown by X-ray crystallography. Chemical Communications, 55. pp. 9116-9119. ISSN 1359-7345 doi: https://doi.org/10.1039/C9CC04316K

McQuaid, K., Abell, H., Gurung, S. P., Allan, D. R., Winter, G., Sorensen, T., Cardin, D. J., Brazier, J. A., Cardin, C. J. and Hall, J. P. (2019) Structural studies reveal the enantiospecific recognition of a DNA G-quadruplex by a ruthenium polypyridyl complex. Angewandte Chemie International Edition, 58 (29). pp. 9881-9885. ISSN 1433-7851 doi: https://doi.org/10.1002/anie.201814502

Strohfeldt, K. (2019) The power of the virtual client – using problem-based learning as a tool for integration in a pharmaceutical sciences laboratory course. Higher Education Pedagogies, 4 (1). pp. 462-475. ISSN 2375-2696 doi: https://doi.org/10.1080/23752696.2019.1686647

Vallance, T. M., Ravishankar, D., Albadawi, D. A. I., Osborn, H. M. I. and Vaiyapuri, S. (2019) Synthetic flavonoids as novel modulators of platelet function and thrombosis. International Journal of Molecular Sciences, 20 (12). e3106. ISSN 1422-0067 doi: https://doi.org/10.3390/ijms20123106

2018

Bootman, M. D., Allman, S., Rietdorf, K. and Bultynck, G. (2018) Deleterious effects of calcium indicators within cells: an inconvenient truth. Cell Calcium, 73. pp. 82-87. ISSN 0143-4160 doi: https://doi.org/10.1016/j.ceca.2018.04.005

Brown, G. D., Bauer, J., Osborn, H. M. I. and Kuemmerle, R. (2018) A solution NMR approach to determine the chemical structures of carbohydrates using the hydroxyl groups as starting points. ACS Omega, 3 (12). pp. 17957-17975. ISSN 2470-1343 doi: https://doi.org/10.1021/acsomega.8b02136

Murray, C. A., Zhu, Z., Cardin, C. J., Colquhoun, H. M. and Greenland, B. W. (2018) Quadruple stacking of macrocyclic viologen radical-cations. Supramolecular Chemistry, 30 (9). pp. 751-757. ISSN 1061-0278 doi: https://doi.org/10.1080/10610278.2017.1375113

Parker, M. P., Murray, C. A., Hart, L. R., Greenland, B. W., Hayes, W., Cardin, C. J. and Colquhoun, H. M. (2018) Mutual complexation between π-π stacked molecular tweezers. Crystal Growth and Design, 18 (1). pp. 386-392. ISSN 1528-7505 doi: https://doi.org/10.1021/acs.cgd.7b01376

Stachulski, A. V., Santoro, M. G., Piacentini, S., Belardo, G., La Frazia, S., Pidathala, C., Row, E. C., Berry, N. G., Iqbal, M., Allman, S. A., Semple, J.E., Eklov, B. M., O'Neill, P. M. and Rossignol, J.-F. (2018) Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus. Future Medicinal Chemistry, 10 (8). pp. 851-862. ISSN 1756-8927 doi: https://doi.org/10.4155/fmc-2017-0217

2017

Hall, J. P., Gurung, S. P., Henle, J., Poidl, P., Andersson, J., Lincoln, P., Winter, G., Sorensen, T., Cardin, D. J., Brazier, J. A. and Cardin, C. J. (2017) Guanine can direct binding specificity of Ru-dppz complexes to DNA through steric effects. Chemistry: A European Journal, 23 (21). pp. 4981-4985. ISSN 0947-6539 doi: https://doi.org/10.1002/chem.201605508

Hart, L. R., Hayes, W. and Greenland, B. W. (2017) Polymeric materials based on NDI and its congeners. In: Pantos, G. D. (ed.) Naphthalenediimide and its Congeners: From Molecules to Materials. Monographs in Supramolecular Chemistry. Royal Society of Chemistry, London, pp. 167-217. ISBN 9781849739221 doi: https://doi.org/10.1039/9781782621386-00167

Natfji, A. A., Osborn, H. M. I. and Greco, F. (2017) Feasibility of polymer-drug conjugates for non-cancer applications. Current Opinion in Colloid & Interface Science, 31. pp. 51-66. ISSN 1359-0294 doi: https://doi.org/10.1016/j.cocis.2017.07.004

Natfji, A. A., Ravishankar, D., Osborn, H. M. I. and Greco, F. (2017) Parameters affecting the enhanced permeability and retention effect: the need for patient selection. Journal of Pharmaceutical Sciences, 106 (11). pp. 3179-3187. ISSN 0022-3549 doi: https://doi.org/10.1016/j.xphs.2017.06.019

Ravishankar, D., Salamah, M., Attina, A., Pothi, R., Vallance, T. M., Javed, M., Williams, H. F., Alzahrani, E. M. S., Kabova, E., Vaiyapuri, R., Shankland, K., Gibbins, J., Strohfeldt, K., Greco, F., Osborn, H. M. I. and Vaiyapuri, S. (2017) Ruthenium-conjugated chrysin analogues modulate platelet activity, thrombus formation and haemostasis with enhanced efficacy. Scientific Reports, 7. 5738. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-017-05936-3

Takahashi, S., Brazier, J. A. and Sugimoto, N. (2017) Topological impact of noncanonical DNA structures on Klenow fragment of DNA polymerase. Proceedings of the National Academy of Sciences of the United States of America, 114 (36). pp. 9605-9610. ISSN 0027-8424 doi: https://doi.org/10.1073/pnas.1704258114

Thomson, R. I., Gardner, R. A., Strohfeldt, K., Fernandes, D. L., Stafford, G. P., Spencer, D. I. R. and Osborn, H. M. I. (2017) Analysis of three epoetin alpha products by LC and LC-MS indicates differences in glycosylation critical quality attributes, including sialic acid content. Analytical Chemistry, 89 (12). pp. 6455-6462. ISSN 0003-2700 doi: https://doi.org/10.1021/acs.analchem.7b00353

2016

Al-Ani, W., Shankland, K. and Cobb, A. J. A. (2016) Asymmetric organocatalytic synthesis of cyclopentane γ-nitroketones. Synlett, 27 (1). pp. 17-20. ISSN 0936-5214 doi: https://doi.org/10.1055/s-0035-1560504

Bovill, R., Evans, P. G., Howse, G. L. and Osborn, H. M. I. (2016) Synthesis and biological analysis of novel glycoside derivatives of L-AEP, as targeted antibacterial agents. Bioorganic & Medicinal Chemistry Letters, 26 (15). pp. 3774-3779. ISSN 0960-894X doi: https://doi.org/10.1016/j.bmcl.2016.05.052

Bryant, L. A., Fanelli, R. and Cobb, A. J. A. (2016) Cupreines and cupreidines: an established class of bifunctional cinchona organocatalysts. Beilstein Journal of Organic Chemistry, 12. pp. 429-443. ISSN 1860-5397 doi: https://doi.org/10.3762/bjoc.12.46

Chen, L., Willcock, H., Wedge, C. J., Hartl, F., Colquhoun, H. M. and Greenland, B. W. (2016) Efficient access to conjugated 4,4’-bipyridinium oligomers using the Zincke reaction: synthesis, spectroscopic and electrochemical properties. Organic and Biomolecular Chemistry, 14 (3). pp. 980-988. ISSN 1477-0520 doi: https://doi.org/10.1039/c5ob02211h

Hall, J. P., Keane, P. M., Beer, H., Buchner, K., Winter, G., Sorensen, T. L., Cardin, D. J., Brazier, J. A. and Cardin, C. J. (2016) Delta chirality ruthenium ‘light-switch’ complexes can bind in the minor groove of DNA with five different binding modes. Nucleic Acids Research, 44 (19). pp. 9472-9482. ISSN 1362-4962 doi: https://doi.org/10.1093/nar/gkw753

Heath, F., Newman, A., Clementi, C., Pasut, G., Lin, H., Stephens, G. J., Whalley, B. J., Osborn, H. M. I. and Greco, F. (2016) A novel PEG–haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer–drug conjugates in a non-prodrug fashion. Polymer Chemistry, 7 (47). pp. 7204-7210. ISSN 1759-9954 doi: https://doi.org/10.1039/c6py01418f

Keane, P. M., Baptista, F. R., Gurung, S. P., Devereux, S. J., Sazanovich, I. V., Towrie, M., Brazier, J. A., Cardin, C. J., Kelly, J. M. and Quinn, S. J. (2016) Long-lived excited-state dynamics of i-motif structures probed by time-resolved infrared spectroscopy. ChemPhysChem, 17 (9). pp. 1281-1287. ISSN 1439-7641 doi: https://doi.org/10.1002/cphc.201501183

Parshotam, J. P., Brazier, J. A., Bovill, R. and Osborn, H. M. I. (2016) An efficient and rapid microwave-assisted synthesis of 1-acetyl-1H-indol-3-YL acetates. Current Microwave Chemistry, 3 (3). pp. 247-257. ISSN 2213-3364 doi: https://doi.org/10.2174/2213335603666160108001556

Ravishankar, D., Corona, G., Hogan, S. M., Spencer, J. P. E., Greco, F. and Osborn, H. M. I. (2016) Thioflavones as novel neuroprotective agents. Bioorganic & Medicinal Chemistry, 24 (21). pp. 5513-5520. ISSN 0968-0896 doi: https://doi.org/10.1016/j.bmc.2016.09.006

Ravishankar, D., Watson, K. A., Greco, F. and Osborn, H. M. I. (2016) Novel synthesised flavone derivatives provide significant insight into the structural features required for enhanced anti-proliferative activity. RSC Advances, 6 (69). pp. 64544-64556. ISSN 2046-2069 doi: https://doi.org/10.1039/C6RA11041J

Sinclair, F., Chen, L., Greenland, B. W. and Shaver, M. P. (2016) Installing multiple functional groups on biodegradable polyesters via post-polymerization olefin cross-metathesis. Macromolecules, 49 (18). pp. 6826-6834. ISSN 0024-9297 doi: https://doi.org/10.1021/acs.macromol.6b01571

2015

Aitken, L. S., Hammond, L. E., Sundaram, R., Shankland, K., Brown, G. D. and Cobb, A. J. A. (2015) Asymmetric cyclopropanation of conjugated cyanosulfones using a novel cupreine organocatalyst: rapid access to d3-amino acids. Chemical Communications, 51 (70). pp. 13558-13561. ISSN 1359-7345 doi: https://doi.org/10.1039/c5cc05158d

Bauer, J. and Osborn, H. M. I. (2015) Sialic acids in biological and therapeutic processes: opportunities and challenges. Future Medicinal Chemistry, 7 (16). pp. 2285-2299. ISSN 1756-8927 doi: https://doi.org/10.4155/fmc.15.135

Gadd, A. J. R., Greco, F., Cobb, A. J. A. and Edwards, A. D. (2015) Targeted activation of toll-like receptors: conjugation of a toll-like receptor 7 agonist to a monoclonal antibody maintains antigen binding and specificity. Bioconjugate Chemistry, 26 (8). pp. 1743-1752. ISSN 1043-1802 doi: https://doi.org/10.1021/acs.bioconjchem.5b00302

Greenland, B. W. and Hayes, W. (2015) Donor-acceptor π−π stacking interactions: from small molecule complexes to healable supramolecular polymer networks. In: Supramolecular polymer networks and gels. Advances in Polymer Science. Springer, pp. 143-166.

Gurung, S. P., Schwarz, C., Hall, J. P., Cardin, C. J. and Brazier, J. A. (2015) The importance of loop length on the stability of i-motif structures. Chemical Communications, 51 (26). pp. 5630-5632. ISSN 1359-7345 doi: https://doi.org/10.1039/C4CC07279K

Hall, J. P., Poynton, F. E., Keane, P. M., Gurung, S. P., Brazier, J. A., Cardin, D. J., Winter, G., Gunnlaugsson, T., Sazanovich, I. V., Towrie, M., Cardin, C. J., Kelly, J. M. and Quinn, S. J. (2015) Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy. Nature Chemistry, 7. pp. 961-967. ISSN 1755-4330 doi: https://doi.org/10.1038/nchem.2369

Kikuta, K., Piao, H., Brazier, J., Taniguchi, Y., Onizuka, K., Nagatsugi, F. and Sasaki, S. (2015) Stabilization of the i-motif structure by the intra-strand cross-link formation. Bioorganic & Medicinal Chemistry Letters, 25 (16). pp. 3307-3310. ISSN 0960-894X doi: https://doi.org/10.1016/j.bmcl.2015.05.064

MacDonald, J. P., Parker, M. P., Greenland, B. W., Hermida-Merino, D., Hamley, I. W. and Shaver, M. P. (2015) Tuning thermal properties and microphase separation in aliphatic polyester ABA copolymers. Polymer Chemistry, 6 (9). pp. 1445-1453. ISSN 1759-9954 doi: https://doi.org/10.1039/c4py01459f

Olorunniji, F. J., McPherson, A. L., Pavlou, H. J., McIlwraith, M. J., Brazier, J., Cosstick, R. and Stark, W. M. (2015) Nicked-site substrates for a serine recombinase reveal enzyme–DNA communications and an essential tethering role of covalent enzyme–DNA linkages. Nucleic Acids Research, 43 (12). pp. 6134-6143. ISSN 1362-4962 doi: https://doi.org/10.1093/nar/gkv521

Ravishankar, D., Watson, K. A., Boateng, S. Y., Green, R. J., Greco, F. and Osborn, H. M.I. (2015) Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal Chemistry, 97. pp. 259-274. ISSN 0223-5234 doi: https://doi.org/10.1016/j.ejmech.2015.04.056

Strohfeldt, K. and Khutoryanskaya, O. (2015) Using problem-based learning in a chemistry practical class for pharmacy students and engaging them with feedback. American Journal of Pharmaceutical Education, 79 (9). 141. ISSN 1553-6467 doi: https://doi.org/10.5688/ajpe799141

2014

Dell'Isola, A., McLachlan, M. M. W., Neuman, B. W., Al-Mullah, H. M. N., Binks, A. W. D., Elvidge, W., Shankland, K. and Cobb, A. J. A. (2014) Synthesis and antiviral properties of spirocyclic [1,2,3]-triazolooxazine nucleosides. Chemistry- A European Journal, 20 (37). pp. 11685-11689. ISSN 0947-6539 doi: https://doi.org/10.1002/chem.201403560

Hart, L. R., Hunter, J. H., Nguyen, N. A., Harries, J. L., Greenland, B. W., Mackay, M. E., Colquhoun, H. M. and Hayes, W. (2014) Multivalency in healable supramolecular polymers: the effect of supramolecular cross-link density on the mechanical properties and healing of noncovalent polymer networks. Polymer Chemistry, 5 (11). pp. 3680-3688. ISSN 1759-9954 doi: https://doi.org/10.1039/C4PY00292J

Harvey, D. J., Edgeworth, M., Krishna, B. A., Bonomelli, C., Allman, S. A., Crispin, M. and Scrivens, J. H. (2014) Fragmentation of negative ions from N-linked carbohydrates: Part 6. Glycans containing oneN-acetylglucosamine in the core. Rapid Communications in Mass Spectrometry, 28 (18). pp. 2008-2018. ISSN 0951-4198 doi: https://doi.org/10.1002/rcm.6980

Rajora, A. K., Ravishankar, D., Osborn, H. M.I. and Greco, F. (2014) Impact of the enhanced permeability and retention (EPR) effect and cathepsins levels on the activity of polymer-drug conjugates. Polymers, 6 (8). pp. 2186-2220. ISSN 2073-4360 doi: https://doi.org/10.3390/polym6082186

Steinke, J. H. G., Greenland, B. W., Johns, S., Parker, M. P., Atkinson, R. C. J., Cade, I. A. and Trussell, S. J. (2014) Robust and operationally simple synthesis of Poly(bis(2,2,2- trifluoroethoxy) phosphazene) with controlled molecular weight, low PDI, and high conversion. ACS Macro Letters, 3. pp. 548-551. ISSN 2161-1653 doi: https://doi.org/10.1021/mz500199x

Vaiyapuri, R., Greenland, B., Colquhoun, H. M., Elliott, J. M. and Hayes, W. (2014) Evolution of supramolecular healable composites: a minireview. Polymer International, 63 (6). pp. 933-942. ISSN 0959-8103 doi: https://doi.org/10.1002/pi.4685

2013

Alonzi, D. S., Kukushkin, N. V., Allman, S. A., Hakki, Z., Williams, S. J., Pierce, L., Dwek, R. A. and Butters, T. D. (2013) Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins. Cellular and Molecular Life Sciences, 70 (15). pp. 2799-2814. ISSN 1420-682X doi: https://doi.org/10.1007/s00018-013-1304-6

Bajaj, N., Hart, L. R., Greenland, B. W. and Hayes, W. (2013) Urea organogelators: synthesis and properties. Macromolecular Symposia, 329 (1). pp. 118-124. ISSN 1022-1360 doi: https://doi.org/10.1002/masy.201200103

Cheng, G., Greenland, B. W., Lampard, C., Williams, N., Bahra, M. S. and Hayes, W. (2013) Lightly branched comb polyesters: application in fast drying solvent-borne coating formulations. Reactive & Functional Polymers, 73 (4). pp. 619-623. ISSN 1381-5148 doi: https://doi.org/10.1016/j.reactfunctpolym.2013.01.008

Cheng, G., Greenland, B. W., Lampard, C., Williams, N., Barhra, M. S. and Hayes, W. (2013) Synthesis of novel hyperbranched polymers featuring oxazoline linear units and their application in fast-drying solvent-borne coating formulations. Journal of Polymer Science Part A: Polymer Chemistry, 51 (18). pp. 3964-3974. ISSN 1099-0518 doi: https://doi.org/10.1002/pola.26807

Cobb, A., Arezki, N., Dell'Isola, A. and Aitken, L. (2013) Asymmetric organocatalysis and the nitro group functionality. Synthesis-Stuttgart, 45 (19). pp. 2627-2648. ISSN 0039-7881 doi: https://doi.org/10.1055/s-0033-1338522

Greenland, B. W. and Hayes, W. (2013) Healable polymeric materials. In: Greenland, B. W. and Hayes, W. (eds.) Healable polymer systems. Royal Society of Chemistry, London, pp. 1-15. ISBN 9781849736268 doi: https://doi.org/10.1039/9781849737470-00001

Greenland, B. W., Bird, M. B., Burattini, S., Cramer, R., O'Reilly, R. K., Patterson, J. P., Hayes, W., Cardin, C. J. and Colquhoun, H. M. (2013) Mutual binding of polymer end-groups by complementary π–π-stacking: a molecular “Roman Handshake”. Chemical Communications, 49 (5). pp. 454-456. ISSN 1359-7345 doi: https://doi.org/10.1039/C2CC35965K

Greenland, B. W., Fiore, G. L., Rowan, S. J. and Weder, C. (2013) Healable supramolecular polymeric materials. In: Hayes, W. and Greenland, B. W. (eds.) Healable Polymer Systems. Royal Society of Chemistry, Cambridge, pp. 92-125. ISBN 9781849736268 doi: https://doi.org/10.1039/9781849737470-00092

Hart, L. R., Harries, J. L., Greenland, B. W., Colquhoun, H. M. and Hayes, W. (2013) Healable supramolecular polymers. Polymer Chemistry, 4. pp. 4860-4870. ISSN 1759-9954 doi: https://doi.org/10.1039/C3PY00081H

Hayes, W. and Greenland, B. W., eds. (2013) Healable Polymer Systems. Royal Society of Chemistry, Cambridge, pp165. ISBN 9781849736268

Jarvis, A. N., McClaren, A. B., Osborn, H. M. I. and Sweeney, J. (2013) Preparation and ring-opening reactions of N-diphenylphosphinyl vinyl aziridines. Beilstein Journal of Organic Chemistry, 9. pp. 852-859. ISSN 1860-5397 doi: https://doi.org/10.3762/bjoc.9.98

Murray, C. A., Cardin, C. J., Greenland, B. W., Swift, A. and Colquhoun, H. M. (2013) Pairwise assembly of organopalladium(II) units with cyanurato(3-) and trithiocyanurato(3-) ligands: formation of chiral Pd12, Pd10 and Pd9 cage-molecules. Inorganic Chemistry, 52 (18). pp. 10424-10430. ISSN 0020-1669 doi: https://doi.org/10.1021/ic401253q

Rajkumar, S., Shankland, K., Goodman, J. M. and Cobb, A. J.A. (2013) Organocatalytic domino reaction of cyanosulfones: access to complex cyclohexane systems with quaternary carbon centers. Organic Letters, 15 (6). pp. 1386-1389. ISSN 1523-7060 doi: https://doi.org/10.1021/ol400356k

Ravishankar, D., Rajora, A., Greco, F. and Osborn, H. (2013) Flavonoids as prospective compounds for anti-cancer therapy. International Journal of Biochemistry and Cell Biology, 45 (12). pp. 2821-2831. ISSN 1878-5875 doi: https://doi.org/10.1016/j.biocel.2013.10.004

Vaiyapuri, R., Greenland, B. W., Colquhoun, H. M., Elliott, J. E. and Hayes, W. (2013) Molecular recognition between functionalized gold nanoparticles and healable, supramolecular polymer blends – a route to property enhancement. Polymer Chemistry, 4. pp. 4902-4909. ISSN 1759-9954 doi: https://doi.org/10.1039/c3py00086a

2012

Brazier, J. A., Shah, A. and Brown, G. D. (2012) I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes. Chemical Communication, 48 (87). pp. 10739-10741. ISSN 1359-7345 doi: https://doi.org/10.1039/C2CC30863K

Rajkumar, S., Shankland, K., Brown, G. D. and Cobb, A. (2012) Organocatalytic enantioselective construction of nitrocyclohexanes containing multiple chiral centres via a cascade reaction. Chemical Science, 3. pp. 584-588. ISSN 1478-6524 doi: https://doi.org/10.1039/C1SC00592H

Rangam, G., Schmitz, K.-M., Cobb, A. and Petersen-Mahrt, S. (2012) AID enzymatic activity is inversely proportional to the size of cytosine C5 orbital cloud. PloS ONE, 7 (8). e43279. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0043279

Shaikh, A. K., Cobb, A. J. A. and Varvounis, G. (2012) Mild and rapid method for the generation of ortho-(naphtho)-quinone methide intermediates. Organic Letters, 14 (2). pp. 584-587. ISSN 1523-7060 doi: https://doi.org/10.1021/ol203196n

2011

Benning, R. K., Osborn, H. M. I. and Turkson, A. (2011) Regioselective Beckmann rearrangements of furanoside and pyranoside-derived oximes. Tetrahedron: Asymmetry, 22 (1). pp. 109-116. ISSN 0957-4166 doi: https://doi.org/10.1016/j.tetasy.2010.11.031

Burland, P. A., Osborn, H. M. I. and Turkson, A. (2011) Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes. Bioorganic & Medicinal Chemistry, 19 (18). pp. 5679-5692. ISSN 0968-0896 doi: https://doi.org/10.1016/j.bmc.2011.07.019

Cobb, A. (2011) General aspects of organocatalytic cyclizations. In: Mahrwald, R. (ed.) Enantioselective Organocatalyzed Reactions II: Asymmetric C-C Bond Formation Processes. Springer, pp. 1-40. ISBN 9789048138661

Fais, M., Karamanska, R., Allman, S., Fairhurst, S. A., Innocenti, P., Fairbanks, A. J., Donohoe, T. J., Davis, B. G., Russell, D. A. and Field, R. A. (2011) Surface plasmon resonance imaging of glycoarrays identifies novel and unnatural carbohydrate-based ligands for potential ricin sensor development. Chemical Science, 2 (10). pp. 1952-1959. ISSN 2041-6539 doi: https://doi.org/10.1039/c1sc00120e

Fante, C., Eldar-Boock, A., Satchi-Fainaro, R., Osborn, H. M. I. and Greco, F. (2011) Synthesis and biological evaluation of a polyglutamic acid-dopamine conjugate: a new antiangiogenic agent. Journal of Medicinal Chemistry, 54 (14). pp. 5255-5259. ISSN 0022-2623 doi: https://doi.org/10.1021/jm200382r

Fern, S. E., Heath, P. and Cobb, A. J. A. (2011) Aldol reaction of butane-2,3-diacetal protected methyl glycerate. Tetrahedron: Asymmetry, 22 (2). pp. 149-152. ISSN 0957-4166 doi: https://doi.org/10.1016/j.tetasy.2011.01.004

Rassmussen, T. S., Allman, S., Twigg, G., Butters, T. D. and Jensen, H. H. (2011) Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease. Bioorganic & Medicinal Chemistry Letters, 21 (5). pp. 1519-1522. ISSN 0960-894X doi: https://doi.org/10.1016/j.bmcl.2010.12.106

Sarsam, S. W., Nutt, D. R., Strohfeldt, K. and Watson, K. A. (2011) Titanocene anticancer complexes and their binding mode of action to human serum albumin: a computational study. Metallomics, 3 (2). pp. 152-161. ISSN 1756-5901 doi: https://doi.org/10.1039/c0mt00041h

Stachulski, A. V., Pidathala, C., Row, E. C., Sharma, R., Berry, N. G., Lawrenson, A. S., Moores, S. L., Iqbal, M., Bentley, J., Allman, S., Edwards, G., Helm, A., Hellier, J., Korba, B. E., Semple, J. E. and Rossignol, J.-F. (2011) Thiazolides as novel antiviral agents. 2. Inhibition of hepatitis C virus replication. Journal of Medicinal Chemistry, 54 (24). pp. 8670-8680. ISSN 0022-2623 doi: https://doi.org/10.1021/jm201264t

Stachulski, A.V., Pidathala, C., Row, E.C., Sharma, R., Berry, N.G., Iqbal, M., Bentley, J., Allman, S.A., Edwards, G., Helm, A., Hellier, J., Korba, B.E., Semple, J.E. and Rossignol, J.-F. (2011) Thiazolides as novel antiviral agents. 1. Inhibition of hepatitis B virus replication. Journal of Medicinal Chemistry, 54 (12). pp. 4119-4132. ISSN 0022-2623 doi: https://doi.org/10.1021/jm200153p

2010

Bauer, J., Stiller, J., Marques-Lopez, E., Strohfeldt, K. A., Christmann, M. and Strohmann , C. (2010) Silyl-Modified Analogues of 2-Tritylpyrrolidine: Synthesis and Applications in Asymmetric Organocatalysis. Chemistry - A European Journal, 16 (42). pp. 12553-12558. ISSN 0947-6539 doi: https://doi.org/10.1002/chem.201002166

Burland, P. A., Coisson, D. and Osborn, H. M. I. (2010) Rapid synthesis of carbohydrate derivatives, including mimetics of c-linked disaccharides and c-Linked aza disaccharides, using the Hetero-Diels−Alder Reaction. Journal of Organic Chemistry, 75 (21). pp. 7210-7218. ISSN 0022-3263 doi: https://doi.org/10.1021/jo101219w

Carlescu, I., Osborn, H. M.I., Desbrieres, J., Scutaru, D. and Popa, M. (2010) Synthesis of poly(aspartimide)-based bio-glycoconjugates. Carbohydrate Research, 345 (1). pp. 33-40. ISSN 0008-6215 doi: https://doi.org/10.1016/j.carres.2009.08.034

Kolstoe, S. E., Mangione, P. P., Bellotti, V., Taylor, G. W., Tennent, G. A., Deroo, S., Morrison, A. J., Cobb, A. J. A., Coyne, A., McCammon, M. G., Warner, T. D., Mitchell, J., Gill, R., Smith, M. D., Ley, S. V., Robinson, S. P. and Pepys, M. B. (2010) Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proceedings of the National Academy of Sciences of the United States of America, 107 (47). pp. 20483-20488. ISSN 0027-8424 doi: https://doi.org/10.1073/pnas.1008255107

Nodes, W. J., Shankland, K., Rajkumar, S. and Cobb, A. J. A. (2010) Asymmetric phase-transfer-catalyzed synthesis of five-membered cyclic gamma-Amino acid precursors. Synlett, 2010 (20). pp. 3011-3014. ISSN 1437-2096 doi: https://doi.org/10.1055/s-0030-1259050

Strohfeldt, K. and Grant, D. T. (2010) A model for self-directed problem-based learning for renal therapeutics. American Journal of Pharmaceutical Education , 74 (9). Article 173.

2009

Allman, S. A., Jensen, H. H., Vijayakrishnan, B., Garnett, J. A., Leon, E., Liu, Y., Anthony, D. C., Sibson, N. R., Feizi, T., Matthews, S. and Davis, B. G. (2009) Potent fluoro-oligosaccharide probes of adhesion in Toxoplasmosis. ChemBioChem, 10 (15). pp. 2522-2529. ISSN 1439-7633 doi: https://doi.org/10.1002/cbic.200900425

Garnett, J. A., Liu, Y., Leon, E., Allman, S. A., Friedrich, N., Saouros, S., Curry, S., Soldati-Favre, D., Davis, B. G., Feizi, T. and Matthews, S. (2009) Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) of Toxoplasma gondii. Protein Science, 18 (9). pp. 1935-1947. ISSN 0961-8368 doi: https://doi.org/10.1002/pro.204

Jawaid, S., Khan, T. H., Osborn, H. M. I. and Williams, N. O. A. (2009) Tyrosinase activated melanoma prodrugs. Anti-cancer agents in medicinal chemistry, 9 (7). pp. 717-727. ISSN 1871-5206

Nodes, W., Nutt, D. R., Chippindale, A. M. and Cobb, A. J. A. (2009) Enantioselective Intramolecular Michael Addition of Nitronates onto Conjugated Esters: Access to Cyclic γ-Amino Acids with up to Three Stereocenters. Journal of the American Chemical Society, 131 (44). pp. 16016-16017. ISSN 0002-7863 doi: https://doi.org/10.1021/ja9070915

Osborn, H. M. I. and Turkson, A. (2009) Synthesis and NMR spectroscopic analysis of 3-nitro-pyranoside, 3-nitro-septanoside and 4-nitro-septanoside derivatives by condensation of the anion of nitromethane with glycoside. Tetrahedron Asymmetry, 20 (18). pp. 2162-2166. ISSN 0957-4166 doi: https://doi.org/10.1016/j.tetasy.2009.08.004

Vessieres, A., Plamont, M.-A., Cabestaing, C., Claffey, J., Dieckmann, S., Hogan, M., Mueller-Bunz, H., Strohfeldt, K. A. and Tacke, M. (2009) Proliferative and anti-proliferative effects of titanium- and iron-based metallocene anti-cancer drugs. Journal of Organometallic Chemistry , 694 (6). pp. 874-879. ISSN 0022-328X doi: https://doi.org/10.1016/j.jorganchem.2008.11.071

2008

Baksh, M. F. and Kelly, P. (2008) Statistical methods for examining genetic influences of resistance to anti-epileptic drugs. Expert Review of Clinical Pharmacology, 1 (1). pp. 137-144. ISSN 1751-2433 doi: https://doi.org/10.1586/17512433.1.1.137

Bonjoch, J., Drew, M. G.B., Gonzalez, A., Greco, F., Jawaid, S., Osborn, H. M. I., Williams, N. A.O. and Yaqoob, P. (2008) Synthesis and evaluation of novel boron-containing complexes of potential use for the selective treatment of malignant melanoma. Journal of Medicinal Chemistry, 51 (20). pp. 6604-6608. ISSN 0022-2623 doi: https://doi.org/10.1021/jm8007745

Ellis, D., Norman, S. E. and Osborn, H. M. I. (2008) Synthesis of S-linked carbohydrate analogues via a Ferrier reaction. Tetrahedron, 64 (12). pp. 2832-2854. ISSN 0040-4020 doi: https://doi.org/10.1016/j.tet.2008.01.042

Strohfeldt, K. A. and Tacke, M. (2008) Bioorganometallic fulvene-derived titanocene anti-cancer drugs. Chemical Society Reviews, 37 (6). pp. 1174-1187. ISSN 0306-0012 doi: https://doi.org/10.1039/b707310k

2007

Campo, V. L., Carvalho, I., Allman, S., Davis, B. G. and Field, R. A. (2007) Chemical and chemoenzymatic synthesis of glycosyl-amino acids and glycopeptides related to Trypanosoma cruzi mucins. Organic & Biomolecular Chemistry, 5 (16). pp. 2645-2657. ISSN 1477-0520 doi: https://doi.org/10.1039/b707772f

Gaynor, J. W., Brazier, J. and Cosstick, R. (2007) Synthesis of 3 '-S-phosphorothiolate oligonucleotides for their potential use in RNA interference. Nucleosides Nucleotides & Nucleic Acids, 26 (6-7). pp. 709-712. ISSN 1525-7770 doi: https://doi.org/10.1080/15257770701490753

2005

Brazier, J. A., Shibata, T., Townsley, J., Taylor, B. F., Frary, E., Williams, N. H. and Williams, D. M. (2005) Amino-functionalized DNA: the properties of C5-amino-alkyl substituted 2′-deoxyuridines and their application in DNA triplex formation. Nucleic Acids Research, 33 (4). pp. 1362-1371. ISSN 1362-4962 doi: https://doi.org/10.1093/nar/gki254