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Three’s a crowd – stabilisation, structure, and applications of DNA triplexes

Dalla Pozza, M., Abdullrahman, A., Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995, Gasser, G. and Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378 (2022) Three’s a crowd – stabilisation, structure, and applications of DNA triplexes. Chemical Science. ISSN 2041-6539

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To link to this item DOI: 10.1039/d2sc01793h

Abstract/Summary

DNA is a strikingly flexible molecule and can form a variety of secondary structures, including the triple helix, which is the subject of this review. The DNA triplex may be formed naturally, during homologous recombination, or can be formed by the introduction of a synthetic triplex forming oligonucleotide (TFO) to a DNA duplex. As the TFO will bind to the duplex with sequence specificity, there is significant interest in developing TFOs with potential therapeutic applications, including using TFOs as a delivery mechanism for compounds able to modify or damage DNA. However, to combine triplexes with functionalised compounds, a full understanding of triplex structure and chemical modification strategies, which may increase triplex stability or in-vivo degradation, is essential – these areas will be discussed in this review. Ruthenium polypyridyl complexes, which are able to photooxidise DNA and act as luminescent DNA probes, may serve as a suitable photophysical payload for a TFO system and the developments in this area in the context of DNA triplexes will also be reviewed.

Item Type:Article
Refereed:Yes
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group
ID Code:106580
Publisher:Royal Society of Chemistry (RSC)

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