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Cyclodextrin-induced suppression of the crystallization of low-molar-mass poly(ethylene glycol)

Hamley, I. W. ORCID: and Castelletto, V. ORCID: (2024) Cyclodextrin-induced suppression of the crystallization of low-molar-mass poly(ethylene glycol). ACS Polymers Au. ISSN 2694-2453 (In Press)

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To link to this item DOI: 10.1021/acspolymersau.4c00024


We examine the effect of alpha-cyclodextrin (αCD) on the crystallization of poly(ethylene glycol) (PEG) [poly(ethylene oxide), PEO] in low-molar-mass polymers, with Mw = 1000, 3000, or 6000 g mol–1. Differential scanning calorimetry (DSC) and simultaneous synchrotron small-/wide-angle X-ray scattering (SAXS/WAXS) show that crystallization of PEG is suppressed by αCD, provided that the cyclodextrin content is sufficient. The PEG crystal structure is replaced by a hexagonal mesophase of αCD-threaded polymer chains. The αCD threading reduces the conformational flexibility of PEG and, hence, suppresses crystallization. These findings point to the use of cyclodextrin additives as a powerful means to tune the crystallization of PEG (PEO), which, in turn, will impact bulk properties including biodegradability.

Item Type:Article
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:116323
Publisher:American Chemical Society


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