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Development and psychometric validation of a patient‑reported outcome measure of recurrent urinary tract infection impact: the Recurrent UTI Impact Questionnaire

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Newlands, A. F. ORCID: https://orcid.org/0000-0002-4718-0075, Roberts, L., Maxwell, K., Kramer, M., Price, J. L. and Finlay, K. A. ORCID: https://orcid.org/0000-0002-8997-2652 (2023) Development and psychometric validation of a patient‑reported outcome measure of recurrent urinary tract infection impact: the Recurrent UTI Impact Questionnaire. Quality of Life Research, 32. pp. 1745-1758. ISSN 1573-2649

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To link to this item DOI: 10.1007/s11136-023-03348-7

Abstract/Summary

Purpose Recurrent urinary tract infection (rUTI) is a highly prevalent condition associated with significant poor quality of life outcomes. A patient-reported outcome measure (PROM) of rUTI-associated psychosocial impact is urgently required to supplement clinical evaluation and validate the challenges experienced by patients. This study therefore developed and validated the Recurrent UTI Impact Questionnaire (RUTIIQ). Methods A rigorous four-stage methodology was followed: (I) concept elicitation through a qualitative survey of the expe- riences of people with rUTI (N = 1983); (II) Delphi expert screening of the RUTIIQ with expert rUTI clinicians (N = 15); (III) one-to-one cognitive interviews with people experiencing rUTI (N = 28) to evaluate the comprehensiveness and com- prehensibility of the RUTIIQ, and (IV) full pilot testing of the RUTIIQ with people experiencing rUTI (N = 240) to perform final item reduction and psychometric analysis. Results Exploratory factor analysis demonstrated a five-factor structure comprising: ‘patient satisfaction’, ‘work and activity interference’, ‘social wellbeing’, ‘personal wellbeing’, and ‘sexual wellbeing’, collectively accounting for 73.8% of the total variance in pilot scores. Results from expert clinicians and patients indicated strong item content validity (I-CVI > .75). The internal consistency and test–retest reliability of the RUTIIQ subscales were excellent (Cronbach’s α = .81–.96, ICC = .66– .91), and construct validity was strong (Spearman’s ρ > .69). Conclusion The RUTIIQ is a 30-item questionnaire with excellent psychometric properties, assessing the patient-reported psychosocial impact of living with rUTI symptoms and pain. This new instrument delivers the unique opportunity to enhance patient-centred care through standardised observation and monitoring of rUTI patient outcomes. Trial registration This study was pre-registered with ClinicalTrials.gov (identifier: NCT05086900).

Item Type:Article
Refereed:Yes
Divisions:Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
Life Sciences > School of Psychology and Clinical Language Sciences > Nutrition and Health
ID Code:121576
Uncontrolled Keywords:Urinary tract infection · Recurrent urinary tract infection · Patient-reported outcomes · Patient-centred care · Women’s health · Chronic pain
Publisher:Springer
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