Accessibility navigation

Dietary vitamin C down-regulates inflammatory gene expression in apoE4 smokers

Majewicz, J., Rimbach, G., Proteggente, A.R., Lodge, J.K., Kraemer, K. and Minihane, A.M. (2005) Dietary vitamin C down-regulates inflammatory gene expression in apoE4 smokers. Biochemical and Biophysical Research Communications, 338 (2). pp. 951-955. ISSN 0006-291X

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1016/j.bbrc.2005.10.029


The deleterious impact of cigarette smoking on cardiovascular health may be in part attributable to a free radical mediated proinflammatory response in circulating monocytes. In the current investigation, the impact of vitamin C supplementation on monocyte gene expression was determined in apoE4 smokers versus non-smokers. A total of 10 smokers and 11 non-smokers consumed 60 mg/day of vitamin C for four weeks and a fasting blood sample was taken at baseline and post-intervention for the determination of plasma vitamin C and monocyte gene expression profiles using cDNA array and real time PCR. In apoE4 smokers, supplementation resulted in a 43% increase in plasma vitamin C concentrations. Furthermore, a number of genes were differentially expressed more than 2-fold in response to treatment, including a downregulation of the proinflammatory mediators tumor necrosis factor (TNF) beta, TNF receptor, neurotrophin-3 growth factor receptor, and monocyte chemoattractant protein I receptor. The study has identified a number of molecular mechanisms underlying the benefit of vitamin C supplementation in smokers. (c) 2005 Elsevier Inc. All rights reserved.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
ID Code:13173
Uncontrolled Keywords:smokers, vitamin C, ApoE genotype, monocytes, inflammation, tumor, necrosis factor beta, monocyte chemoattractant protein 1, tyrosine, receptor kinase-beta, microarray, APOLIPOPROTEIN-E GENOTYPE, CORONARY-HEART-DISEASE, TUMOR-NECROSIS-FACTOR, BLOOD MONONUCLEAR-CELLS, KAPPA-B ACTIVATION, CARDIOVASCULAR-DISEASE, CIGARETTE-SMOKING, TOBACCO-SMOKE, ASCORBIC-ACID, FACTOR-ALPHA

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation