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alpha-tocopherol affects androgen metabolism in male rat

Barella, L., Rota, C., Stocklin, E. and Rimbach, G. (2004) alpha-tocopherol affects androgen metabolism in male rat. In: Conference on Vitamin E and Health, Boston, MA, pp. 334-336,

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To link to this item DOI: 10.1196/annals.1331.036


The Alpha-Tocopherol Beta-Carotene Cancer Prevention Study has provided the first evidence implicating vitamin E in hormone synthesis. The effect of vitamin E on stereoidogenesis in testes and adrenal glands was assessed in growing rats using Affymetrix gene-chip technology. Dietary supplementation of rats with vitamin E (60 mg/kg feed) for a period of 429 days caused a significant repression of genes encoding for proteins centrally involved in the uptake (low-density lipoprotein receptor) and de novo synthesis (for example, 7-dehydrocholesterol reductase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, isopentenyl-diphosphate delta-isomerase, and farnesyl pyrophosphate synthetase) of cholesterol, the precursor of all steroid hormones. The present investigation indicates that dietary vitamin E may induce changes in stereoidogenesis by affecting cholesterol homeostasis.

Item Type:Conference or Workshop Item (Paper)
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
ID Code:13567
Uncontrolled Keywords:vitamin E, hormone, androgen, gene expression, testes, adrenal, cholesterol
Publisher:New York Acad Sciences

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