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Disorder and dissolution enhancement: Deposition of ibuprofen on to insoluble polymers

Williams, A. C. ORCID:, Timmins, P., Lu, M. C. and Forbes, R. T. (2005) Disorder and dissolution enhancement: Deposition of ibuprofen on to insoluble polymers. European Journal of Pharmaceutical Sciences, 26 (3-4). pp. 288-294. ISSN 0928-0987

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To link to this item DOI: 10.1016/j.ejps.2005.06.006


Microcrystalline cellulose (MCC) and cross-linked polyvinylpyrrolidone (PVP-CL) were examined as polymeric carriers to support amorphous ibuprofen (IB). Drug/cartier systems were prepared as physical mixes, and drug was loaded onto the polymers by hot mix and solvent deposition methods. The systems were examined using differential scanning calorimetry (DSC), X-ray powder diffractometry (XRD) and by dissolution testing. PVP-CL reduced drug crystallinity more than MCC and, surprisingly, even very simple mixing of ibuprofen with PVP-CL induced disordering of the drug. Increased ibuprofen dissolution rates were achieved with both polymers, in the order of solvent deposition > hot mixes > physical mixes. The increased dissolution rates could be attributed to a combination of faster dissolution from amorphous ibuprofen, microcrystalline drug deposition on carrier surfaces and polymer swelling. However, no clear relationship was observed between ibuprofen dissolution rates (using first order, Higuchi or Hixson-Crowell relationships) and drug crystallinity. (C) 2005 Elsevier B.V. All rights reserved.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
ID Code:13614
Uncontrolled Keywords:solvent deposition, hot mixing, cross-linked polyvinylpyrrolidone, amorphous, dissolution rate, WATER-SOLUBLE DRUGS, SOLID DISPERSIONS, RELEASE, TABLETS, POLYVINYLPYRROLIDONE, CROSPOVIDONE, ADSORBENTS, SOLUBILITY, AGITATION, CELLULOSE

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