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Development of new methodologies for entry to targets of therapeutic interest

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Osborn, H.M.I. ORCID: https://orcid.org/0000-0002-0683-0457 (2005) Development of new methodologies for entry to targets of therapeutic interest. Synlett (17). pp. 2571-2586. ISSN 0936-5214

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To link to this item DOI: 10.1055/s-2005-917076

Abstract/Summary

This Account provides an overview of strategies that have been reported from our laboratories for the synthesis of targets of therapeutic interest, namely carbohydrates, and prodrugs for the treatment of melanoma. These programmes have involved the development of new synthetic methodologies including the regio- and stereoselective synthesis of specific carbohydrate isomers, and new protecting group methodologies. This review provides an insight into the progress of these research themes, and suggests some applications for the targets that are currently being explored.

Item Type:Article
Refereed:Yes
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
ID Code:13670
Uncontrolled Keywords:carbohydrates, prodrugs, regioselective, stereoselective, melanoma, LIPASE-CATALYZED ACYLATION, DIRECT CHEMICAL-SYNTHESIS, ALPHA-LINKED, GLCNAC, ONE-POT SYNTHESIS, ANOMERIC SUBSTITUENTS, MALIGNANT-MELANOMA, GLYCOSIDASE INHIBITORS, ESCHERICHIA-COLI, REGIOSELECTIVE, C-3-O-ACYLATION, PROTECTING GROUPS
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