Characterisation of cyclin D1 down-regulation in coronavirus infected cellsHarrison, S.M., Dove, B.K., Rothwell, L., Kaiser, P., Tarpey, I., Brooks, G. and Hiscox, J.A. (2007) Characterisation of cyclin D1 down-regulation in coronavirus infected cells. FEBS Letters, 581 (7). pp. 1275-1286. ISSN 0014-5793 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1016/j.febslet.2007.02.039 Abstract/SummaryThe positive strand RNA coronavirus, infectious bronchitis virus (IBV), induces a G2/M phase arrest and reduction in the G1 and G1/S phase transition regulator cyclin D1. Quantitative real-time RT-PCR and Western blot analysis demonstrated that cyclin D1 was reduced post-transcriptionally within infected cells independently of the cell-cycle stage at the time of infection. Confocal microscopy revealed that cyclin D1 decreased in IBV-infected cells as infection progressed and inhibition studies indicated that a population of cyclin D1 could be targeted for degradation by a virus mediated pathway. In contrast to the SARS-coronavirus, IBV nucleocapsid protein did not interact with cyclin D1. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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