Accessibility navigation

Regulation of platelet biology by platelet endothelial cell adhesion molecule-1.

Jones, C. I. ORCID:, Moraes, L. A. and Gibbins, J. M. ORCID: (2012) Regulation of platelet biology by platelet endothelial cell adhesion molecule-1. Platelets, 23 (5). pp. 331-335. ISSN 1369-1635

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.3109/09537104.2011.626091


Platelet endothelial cell adhesion molecule-1 (PECAM-1), an immunoreceptor tyrosine-based inhibitory motif containing receptor, plays diverse and apparently contradictory roles in regulating the response of platelets to stimuli; inhibiting platelet response to immunoreceptor tyrosine-based activation motif and G protein-coupled receptor signalling following stimulation with collagen, adenosine diphosphate, and thrombin, as well as enhancing integrin outside-in signalling. These dual, and opposing, roles suggest an important and complex role for PECAM-1 in orchestrating platelet response to vascular damage. Indeed, during thrombus formation, the influence of PECAM-1 on the multiple signalling pathways combines leading to a relatively large inhibitory effect on thrombus formation.

Item Type:Article
Divisions:Life Sciences > School of Biological Sciences > Biomedical Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:26122
Uncontrolled Keywords:Platelet, PECAM-1, ITIM, haemostasis, thrombosis
Publisher:Informa Healthcare

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation