Insect infection model for campylobacter jejuni reveals that O-methyl phosphoramidate has insecticidal activityChampion, O. L., Karlyshev, A. V., Senior, N. J., Woodward, M. J., La Ragione, R., Howard, S. L., Wren, B. W. and Titball, R. W. (2010) Insect infection model for campylobacter jejuni reveals that O-methyl phosphoramidate has insecticidal activity. Journal of Infectious Diseases, 201 (5). pp. 776-782. ISSN 0022-1899 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1086/650494 Abstract/SummaryGalleria mellonella (wax moth) larvae have elsewhere been shown to be susceptible to pathogens such as Francisella tularensis, Burkholderia mallei, and Pseudomonas aeruginosa. We report that the larvae are rapidly killed by Campylobacter jejuni at 37 degrees C. Three strains of C. jejuni tested, 11168H (human diarrheal isolate), G1 (human Guillain-Barre syndrome isolate), and 81-176 (human diarrheal isolate), were equally effective at killing G. mellonella larvae. A panel of defined mutants of C. jejuni 11168H, in known or putative virulence genes, showed different degrees of attenuation in G. mellonella larvae. A mutant lacking the O-methyl phosphoramidate (MeOPN) capsule side group was attenuated, clearly demonstrating that MeOPN has a role in virulence. This new model of C. jejuni infection should facilitate the identification of novel virulence genes.
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