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Optimizing layer-by-layer deposition of interpolymer complexes on solid substrates using Biacore

Bizley, S. C., Williams, A. C. ORCID:, Kemp, F. and Khutoryanskiy, V. V. ORCID: (2012) Optimizing layer-by-layer deposition of interpolymer complexes on solid substrates using Biacore. Soft Matter, 8 (25). pp. 6782-6787. ISSN 1744-683X

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To link to this item DOI: 10.1039/C2SM25652E


The layer-by-layer deposition of polymers onto surfaces allows the fabrication of multilayered materials for a wide range of applications, from drug delivery to biosensors. This work describes the analysis of complex formation between poly(acrylic acid) and methylcellulose in aqueous solutions using Biacore, a surface plasmon resonance analytical technique, traditionally used to examine biological interactions. This technique characterized the layer-by-layer deposition of these polymers on the surface of a Biacore sensor chip. The results were subsequently used to optimize the experimental conditions for sequential layer deposition on glass slides. The role of the solution pH and poly(acrylic acid) molecular weight on the formation of interpolymer multilayered coatings was researched, and showed that the optimal deposition of the polymer complexes was achieved at pHs ≤2.5 with a poly(acrylic acid) molecular weight of 450 kDa.

Item Type:Article
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Thermal Analysis (CAF)
Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
ID Code:28428
Publisher:Royal Society of Chemistry

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