Attaching and effacing lesions caused by Escherichia coli O157:H7 in experimentally inoculated neonatal lambsWales, A. D., Pearson, G. R., Skuse, A. M., Roe, J. M., Hayes, C. M., Cookson, A. L. and Woodward, M. J. (2001) Attaching and effacing lesions caused by Escherichia coli O157:H7 in experimentally inoculated neonatal lambs. Journal of Medical Microbiology, 50 (9). pp. 752-758. ISSN 0022-2615 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. Official URL: http://jmm.sgmjournals.org/content/50/9.toc Abstract/SummaryFour 6-day-old conventionally reared lambs were inoculated orally with a total of 10(9) cfu comprising equal numbers of four enterohaemorrhagic Escherichia coli (EHEC) O157:H7 strains. All animals remained clinically normal. Tissues were sampled under terminal anaesthesia at 12, 36, 60 and 84 h post inoculation (hpi). EHEC O157:H7 was cultured from most gastrointestinal tract sites. Small, sparse attaching and effacing (AE) lesions were found in the caecum at 12 and 36 hpi and in the terminal colon and rectum at 84 hpi. Organisms in the lesions were labelled specifically by an O157 antiserum. The results indicate that the well-characterised mechanisms for intimate attachment encoded by the locus for enterocyte effacement (LEE) of EHEC O157:H7 may contribute to the initial events. at least, of colonisation of sheep.
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