Accessibility navigation

Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current

Dallas, M. L. ORCID:, Yang, Z., Boyle, J. P., Boycott, H. E., Scragg, J. L., Milligan, C. J., Elies, J., Duke, A., Thireau, J., Reboul, C., Richard, S., Bernus, O., Steele, D. S. and Peers, C. (2012) Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current. American Journal of Respiratory and Critical Care Medicine, 186 (7). pp. 648-656. ISSN 1535-4970

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1164/rccm.201204-0688OC


Our data indicate that the proarrhythmic effects of CO arise from activation of NO synthase, leading to NO-mediated nitrosylation of Na(V)1.5 and to induction of the late Na(+) current. We also show that the antianginal drug ranolazine can abolish CO-induced early after-depolarizations, highlighting a novel approach to the treatment of CO-induced arrhythmias.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
No Reading authors. Back catalogue items
ID Code:30338
Uncontrolled Keywords:carbon monoxide; arrhythmia; late Na+ channel; nitric oxide; S-nitrosylation
Publisher:American Thoracic Society

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation