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Hippurate: the natural history of a mammalian-microbial co-metabolite

Lees, H. J., Swann, J. R., Wilson, I. D., Nicholson, J. K. and Holmes, E. (2013) Hippurate: the natural history of a mammalian-microbial co-metabolite. Journal of Proteome Research, 12 (4). pp. 1527-1546. ISSN 1535-3907

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To link to this item DOI: 10.1021/pr300900b


Hippurate, the glycine conjugate of benzoic acid, is a normal constituent of the endogenous urinary metabolite profile and has long been associated with the microbial degradation of certain dietary components, hepatic function and toluene exposure, and is also commonly used as a measure of renal clearance. Here we discuss the potential relevance of hippurate excretion with regards to normal endogenous metabolism and trends in excretion relating to gender, age, and the intestinal microbiota. Additionally, the significance of hippurate excretion with regards to disease states including obesity, diabetes, gastrointestinal diseases, impaired renal function, psychological disorders and autism, as well as toxicity and parasitic infection, are considered.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Food Microbial Sciences Research Group
ID Code:33294
Publisher:American Chemical Society


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