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Identification of novel cholesteatoma-related gene expression signatures using full-genome microarrays

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Klenke, C., Janowski, S., Borck, D., Widera, D. ORCID: https://orcid.org/0000-0003-1686-130X, Ebmeyer, J., Kalinowski, J., Leichtle, A., Hofestädt, R., Upile, T., Kaltschmidt, C., Kaltschmidt, B. and Sudhoff, H. (2012) Identification of novel cholesteatoma-related gene expression signatures using full-genome microarrays. PLoS ONE, 7 (12). e52718. ISSN 1932-6203

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To link to this item DOI: 10.1371/journal.pone.0052718

Abstract/Summary

This study demonstrates that the expression profile of cholesteatoma is similar to a metastatic tumour and chronically inflamed tissue. Based on the investigated profiles we present novel protein-protein interaction and signal transduction networks, which include cholesteatoma-regulated transcripts and may be of great value for drug targeting and therapy development.

Item Type:Article
Refereed:Yes
Divisions:No Reading authors. Back catalogue items
Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
ID Code:39515
Publisher:Public Library of Science
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