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Self-assembly of the cyclic lipopeptide daptomycin: spherical micelle formation does not depend on the presence of calcium chloride

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Kirkham, S., Castelletto, V., Hamley, I. ORCID: https://orcid.org/0000-0002-4549-0926, Inoue, K., Rambo, R., Reza, M. and Ruokolainen, J. (2016) Self-assembly of the cyclic lipopeptide daptomycin: spherical micelle formation does not depend on the presence of calcium chloride. ChemPhysChem, 17 (14). pp. 2118-2122. ISSN 1439-7641

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To link to this item DOI: 10.1002/cphc.201600308

Abstract/Summary

The cyclic lipopeptide Daptomycin, used as a treatment for infections where antimicrobial resistance is observed, is shown to self-assemble into spherical micelles above a critical aggregation concentration. Micelles are observed either in the absence or presence of CaCl2, in contrast to claims in the literature that CaCl2 is required for micellization.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:66618
Publisher:Wiley
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