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Stabilization of long-looped i-motif DNA by polypyridyl ruthenium complexes

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Pages, B. J., Gurung, S. P., McQuaid, K. ORCID: https://orcid.org/0000-0002-3222-5584, Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 and Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X (2019) Stabilization of long-looped i-motif DNA by polypyridyl ruthenium complexes. Frontiers in Chemistry, 7. 744. ISSN 2296-2646

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To link to this item DOI: 10.3389/fchem.2019.00744

Abstract/Summary

A spectroscopic study of the interactions of Λ- and Δ-[Ru(phen)2(dppz)]2+ with i-motif DNA containing thymine loops of various lengths. In the presence of i-motifs, the luminescence of the Λ enantiomer was enhanced much more than the Δ. Despite this, the effect of each enantiomer on i-motif thermal stability was comparable. The sequences most affected by [Ru(phen)2(dppz)]2+ were those with long thymine loops; this suggests that long-looped i-motifs are attractive targets for potential transition metal complex drugs and should be explored further in drug design.

Item Type:Article
Refereed:Yes
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:87365
Uncontrolled Keywords:Chemistry, i-motif, DNA, ruthenium, melting, stabilization, luminescence
Publisher:Frontiers Media S.A.
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