Accessibility navigation

Platelet alpha-granules contribute to organ-specific pathologies in a mouse model of severe malaria

Darling, T. K., Schenk, M. P., Zhou, C., Maloba, F. M., Mimche, P. N., Gibbins, J. M. ORCID:, Jobe, S. M. and Lamb, T. J. (2020) Platelet alpha-granules contribute to organ-specific pathologies in a mouse model of severe malaria. Blood Advances, 4 (1). pp. 1-8. ISSN 2473-9529

Text - Published Version
· Please see our End User Agreement before downloading.

[img] Text - Accepted Version
· Restricted to Repository staff only


It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1182/bloodadvances.2019000773


Cerebral malaria (CM) and malaria-associated acute lung injury/acute respiratory distress syndrome (MA-ALI/ARDS) are among the most severe complications of Plasmodium infection. While these disease manifestations are multifactorial, platelets have been described to play a role in the development of both syndromes in humans1,2 and mice3,4. Although the impact of platelets on malaria has been well-studied, questions remains with regard to their contribution to parasite control and immunopathogenesis. Studies have indicated that platelets can kill Plasmodium-infected red blood cells (iRBCs)5-8. However, there are contrasting reports that platelets do not exert any significant control over parasite growth but rather exacerbate malaria immunopathology3,9-12. In this study, we address the role of platelets in the development of severe malaria in three different mouse models of platelet dysfunction/depletion. We show a key role for platelets, and particularly platelet alpha granules (-granules), in mediating organ-specific pathologies during rodent Plasmodium infection.

Item Type:Article
Divisions:Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:87452
Publisher:American Society of Hematology


Downloads per month over past year

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation