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N-3 polyunsaturated fatty acids and inflammation in the arterial wall

Yaqoob, P. and Calder, P. C. (2003) N-3 polyunsaturated fatty acids and inflammation in the arterial wall. European Journal of Medical Research, 8 (8). pp. 337-354. ISSN 0949-2321

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Abstract/Summary

Atherosclerosis, leading to cardiovascular disease, is a chronic condition involving a strong inflammatory component. There is evidence that the n-3 polyunsaturated fatty acids (PUFA) present in oily fish and fish oils protect against cardiovascular disease. While these fatty acids have well-recognised effects on plasma triacylglycerol concentrations, it is likely that they exert beneficial effects through other mechanisms in addition. A large body of evidence suggests that the n-3 PUFA have anti-inflammatory properties, some of which may be manifested in the arterial wall, either directly or indirectly, to modulate the progression of atherosclerosis. This review critically evaluates the evidence for the anti-inflammatory effects of the n-3 PUFA in cells and on pathways which have a direct influence on atherogenesis in the arterial wall.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:12832
Uncontrolled Keywords:n-3 polyunsaturated fatty acids, fish oils, atherosclerosis, cardiovascular disease, inflammation, CORONARY-HEART-DISEASE, LOW-DENSITY-LIPOPROTEIN, C-REACTIVE PROTEIN, PROLIFERATOR-ACTIVATED RECEPTOR, FISH-OIL SUPPLEMENTATION, TUMOR-NECROSIS-FACTOR, LONG-CHAIN N-3, HUMAN ATHEROSCLEROTIC PLAQUES, SMOOTH-MUSCLE-CELLS, INTERCELLULAR-ADHESION MOLECULE-1

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