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Fatty acids as gatekeepers of immune cell regulation

Yaqoob, P. (2003) Fatty acids as gatekeepers of immune cell regulation. Trends in Immunology, 24 (12). pp. 639-645. ISSN 1471-4906

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To link to this article DOI: 10.1016/j.it.2003.10.002

Abstract/Summary

Fatty acids have diverse roles in all cells. They are important as a source of energy, as structural components of cell membranes, as signalling molecules and as precursors for the synthesis of eicosanoids. Recent research has suggested that the organization of fatty acids into distinct cellular pools has a particularly important role in cells of the immune system and that forms of lipid trafficking exist, which are as yet poorly understood. This Review examines the nature and regulation of cellular lipid pools in the immune system, their delivery of fatty acids or fatty acid derivatives to specific locations and their potential role in health and disease.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:12837
Uncontrolled Keywords:PROLIFERATOR-ACTIVATED RECEPTORS, LIPID BODY FORMATION, PPAR-GAMMA, SIGNAL-TRANSDUCTION, GENE-EXPRESSION, T-LYMPHOCYTES, DIETARY, SUPPLEMENTATION, MEMBRANE MICRODOMAINS, EICOSAPENTAENOIC ACID, HYPOLIPIDEMIC DRUGS

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