Accessibility navigation


Fecal microbiota in patients receiving enteral feeding are highly variable and may be altered in those who develop diarrhea

Whelan, K., Judd, P.A., Tuohy, K.M., Gibson, G.R., Preedy, V.R. and Taylor, M.A. (2009) Fecal microbiota in patients receiving enteral feeding are highly variable and may be altered in those who develop diarrhea. American Journal of Clinical Nutrition, 89 (1). pp. 240-247. ISSN 0002-9165

Full text not archived in this repository.

To link to this article DOI: 10.3945/ajcn.2008.26219

Abstract/Summary

Background: The pathogenesis of diarrhea in patients receiving enteral feeding includes colonic water secretion, antibiotic prescription, and enteropathogenic colonization, each of which involves an interaction with the gastrointestinal microbiota. Objective: The objective was to investigate temporal changes in the concentrations of fecal microbiota and short-chain fatty acids (SCFAs) in patients starting 14-d of enteral feeding and to compare these changes between patients who do and do not develop diarrhea. Design: Twenty patients starting exclusive nasogastric enteral feeding were monitored for 14 d. Fecal samples were collected at the start, middle, and end of this period and were analyzed for major bacterial groups by using culture independent fluorescence in situ hybridization and for SCFAs by using gas-liquid chromatography. Results: Although no significant changes in fecal microbiota or SCFAs were observed during enteral feeding, stark alterations occurred within individual patients. Ten patients (50%) developed diarrhea, and these patients had significantly higher concentrations of clostridia (P = 0.026) and lower concentrations (P = 0.069) and proportions (P = 0.029) of bifidobacteria. Patients with and without diarrhea had differences in the proportion of bifidobacteria (median: 0.4% and 3.7%; interquartile range: 0.8 compared with 4.3; P = 0.035) and clostridia (median: 10.4% and 3.7%; interquartile range: 14.7 compared with 7.0; P = 0.063), respectively, even at the start of enteral feeding. Patients who developed diarrhea had higher concentrations of total fecal SCFAs (P = 0.044), acetate (P = 0.029), and butyrate (P = 0.055). Conclusion: Intestinal dysbiosis occurs in patients who develop diarrhea during enteral feeding and may be involved in its pathogenesis. Am J Clin Nutr 2009; 89: 240-7.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
ID Code:12862
Uncontrolled Keywords:CHAIN FATTY-ACIDS, IN-SITU HYBRIDIZATION, PLACEBO-CONTROLLED TRIAL, TUBE-FED PATIENTS, RNA-BASED PROBES, OLIGONUCLEOTIDE PROBES, HOSPITALIZED-PATIENTS, DISTAL COLON, HUMAN FECES, NUTRITION

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation