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Evidence for associations between common polymorphisms of estrogen receptor beta gene with homocysteine and nitric oxide

Reimann, M., Vafeiadou, K., Hall, W.L., Dierkes, J., Nilsson, M., Dahlman-Wright, K., Ferrari, M., Huebner, U., Hallund, J., Bugel, S., Branca, F., Wilhams, C.M. and Koebnick, C. (2006) Evidence for associations between common polymorphisms of estrogen receptor beta gene with homocysteine and nitric oxide. Climacteric, 9 (3). pp. 215-223. ISSN 1369-7137

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To link to this item DOI: 10.1080/13697130600733758

Abstract/Summary

Background Homocysteine and asymmetric dimethylarginine (ADMA) affect nitric oxide (NO) concentration, thereby contributing to cardiovascular disease (CVD). Both amino acids can be reduced in vivo by estrogen. Variation in the estrogen receptor (ER) may influence homocysteine and ADMA, yet no information is available on associations with single nucleotide polymorphisms in the estrogen receptor genes ER alpha (PvuII and XbaI) and ER beta (1730G -> A and cx+56 G -> A). Objective To find relationships between common polymorphisms associated with cardiovascular disease and cardiovascular risk factors homocysteine and ADMA. Methods In a cross-sectional study with healthy postmenopausal women (n = 89), homocysteine, ADMA, nitric oxide metabolites (NOx), plasma folate and ER alpha and beta polymorphisms ER alpha PvuII, ER alpha XbaI; ER beta 1730G -> A (AluI), ER beta cx+56 G -> A (Tsp5091) were analyzed. Results Women who are homozygotic for ER beta cx+56 G -> A A/A exhibited higher homocysteine (p = 0.012) and NOx (p = 0.056) levels than wildtype or heterozygotes. NOx concentration was also significantly affected by ER beta 1730 G -> A polymorphism (p = 0.025). The ER beta (p < 0.001) and ER alpha (p < 0.001) polymorphisms were in linkage disequilibrium. Conclusions Women who are homozygotic for ER beta cx+S6 G -> A A/A may be at increased risk for cardiovascular disease due to higher homocysteine levels.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
ID Code:13052
Uncontrolled Keywords:single nucleotide polymorphism, estrogen receptor, homocysteine, asymmetric dimethylarginine, nitric oxide, INDUCED ENDOTHELIAL DYSFUNCTION, CELLULAR REDOX STATE, POSTMENOPAUSAL, WOMEN, DEFICIENT MICE, ASYMMETRICAL DIMETHYLARGININE, LINKAGE, DISEQUILIBRIUM, REPLACEMENT THERAPY, PLASMA HOMOCYSTEINE, MESSENGER-RNA, BREAST-CANCER

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