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Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations

Miles, E. A., Rees, D., Banerjee, T., Cazzola, R., Lewis, S., Wood, R., Oates, R., Tallant, A., Cestaro, B., Yaqoob, P., Wahle, K. W. J. and Calder, P. C. (2008) Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations. Atherosclerosis, 196 (1). pp. 298-305. ISSN 0021-9150

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To link to this article DOI: 10.1016/j.atherosclerosis.2006.11.002

Abstract/Summary

Objective: To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these. Methods and results: Cytokines (IL-6, IL-18), chemokines (6Ckine, MCP-1, IP-10), soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and adipokines (adiponectin) were measured in the plasma of healthy male subjects aged 18-84 years (n = 162). These were related to known cardiovascular risk factors (age, BMI, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, HDL cholesterol and triacylglycerol concentrations) in order to identify significant associations. Plasma concentrations of sVCAM-1, sE-selectin, IL-6, IL-18, MCP-1, 6Ckine, IP-10 and adiponectin, but not sICAM-1, were significantly positively correlated with age, as well as with several other cardiovascular risk factors. The correlations with other risk factors disappeared when age was controlled for. In contrast, the correlations with age remained significant for sVCAM-1, IL-6, MCP-1, 6Ckine and IP-10 when other cardiovascular risk factors were controlled for. Conclusions: Plasma concentrations of some inflammatory markers (sVCAM-1, IL-6, MCP-L 6Ckine, IP-10) are positively correlated with age, independent of other cardiovascular risk factors. This suggests that age-related inflammation may not be driven by recognised risk factors. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:13148
Uncontrolled Keywords:aging, cardiovascular disease, chemokine, inflammation, soluble, adhesion molecule, MONOCYTE CHEMOATTRACTANT PROTEIN-1, SOLUBLE ADHESION MOLECULES, CORONARY-HEART-DISEASE, PLASMA ADIPONECTIN CONCENTRATION, PERIPHERAL, ARTERIAL-DISEASE, CARDIOVASCULAR RISK-FACTORS, C-REACTIVE PROTEIN, MYOCARDIAL-INFARCTION, SERUM-LEVELS, VASCULAR-DISEASE

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