Accessibility navigation


Using pH abnormalities in diseased skin to trigger and target topical therapy

Downloads

Downloads per month over past year

Rizi, K., Green, R. J., Donaldson, M. X. and Williams, A. C. (2011) Using pH abnormalities in diseased skin to trigger and target topical therapy. Pharmaceutical Research, 28 (10). pp. 2589-2598. ISSN 0724-8741

[img] Text - Accepted Version
· Please see our End User Agreement before downloading.

353Kb

To link to this article DOI: 10.1007/s11095-011-0488-4

Abstract/Summary

Abstract Purpose: The pH discrepancy between healthy and atopic dermatitis skin was identified as a site specific trigger for delivering hydrocortisone from microcapsules. Methods: Using Eudragit L100, a pH-responsive polymer which dissolves at pH 6, hydrocortisone-loaded microparticles were produced by oil-in-oil microencapsulation or spray drying. Release and permeation of hydrocortisone from microparticles alone or in gels was assessed and preliminary stability data was determined. Results: Drug release from microparticles was pH-dependent though the particles produced by spray drying also gave significant non-pH dependent burst release, resulting from their porous nature or from drug enrichment on the surface of these particles. This pH-responsive release was maintained upon incorporation of the oil-in-oil microparticles into Carbopol- and HPMC-based gel formulations. In-vitro studies showed 4 to 5-fold higher drug permeation through porcine skin from the gels at pH 7 compared to pH 5. Conclusions: Permeation studies showed that the oil-in-oil generated particles deliver essentially no drug at normal (intact) skin pH (5.0 – 5.5) but that delivery can be triggered and targeted to atopic dermatitis skin where the pH is elevated. The incorporation of these microparticles into Carbopol- and HPMC-based aqueous gel formulations demonstrated good stability and pH-responsive permeation into porcine skin.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
ID Code:21364
Publisher:Springer Verlag

Download Statistics for this item.

Centaur Editors: Update this record

Page navigation