Adjuvant chemotherapy in older women (ACTION) study - what did we learn from the pilot phase?
Leonard, R., Ballinger, R., Cameron, D., Ellis, P., Fallowfield, L., Gosney, M., Johnson, L., Kilburn, L. S., Makris, A., Mansi, J., Reed, M., Ring, A., Robinson, A., Simmonds, P., Thomas, G. and Bliss, J. M. (2011) Adjuvant chemotherapy in older women (ACTION) study - what did we learn from the pilot phase? British Journal of Cancer, 105 (9). pp. 1260-1266. ISSN 0007-0920
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To link to this article DOI: 10.1038/bjc.2011.377
Despite widespread support at several public meetings, input from patient groups including representation on the Trial Management Group, the trial failed to recruit due to the inability to convince patients to accept randomisation. It would therefore seem that randomising the patients to receive chemotherapy vs observation is not a viable design in the current era for this patient population.
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