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Tracking (poly)phenol components from raspberries in ileal fluid

McDougall, G. J., Connor, S., Pereira-Caro, G., González-Barrio, R., Brown, E. M., Verrall, S., Stewart, D., Moffet, T., Ibars, M., Lawther, R., O'Connor, G., Rowland, I., Crozier, A. and Gill, C. I. R. (2014) Tracking (poly)phenol components from raspberries in ileal fluid. Journal of Agricultural and Food Chemistry, 62 (30). pp. 7631-7641. ISSN 0021-8561

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To link to this item DOI: 10.1021/jf502259j

Abstract/Summary

The (poly)phenols in ileal fluid after ingestion of raspberries were analysed by targeted and non-targeted LC-MSn approaches. Targeted approaches identified major anthocyanin and ellagitannin components at varying recoveries and with considerable inter-individual variation. Non-targeted LC-MSn analysis using an Orbitrap mass spectrometer gave exact mass MS data which was sifted using a software program to select peaks that changed significantly after supplementation. This method confirmed the recovery of the targeted components but also identified novel raspberry-specific metabolites. Some components (including ellagitannin and previously unidentified proanthocyanidin derivatives) may have arisen from raspberry seeds that survived intact in ileal samples. Other components include potential breakdown products of anthocyanins, unidentified components and phenolic metabolites formed in either the gut epithelia or after absorption into the circulatory system and efflux back into the gut lumen. The possible physiological roles of the ileal metabolites in the large bowel are discussed.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:37149
Uncontrolled Keywords:polyphenols; digestion; bioactivity; gut health; bioavailability; metabolism
Publisher:American Chemical Society

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