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Reversal of a single base pair step controls guanine photo-oxidation by an intercalating Ru(II) dipyridophenazine complex

Keane, P. M., Poynton, F. E., Hall, J. P., Sazanovich, I. V., Towrie, M., Gunnlaugsson, T., Quinn, S. J., Cardin, C. J. and Kelly, J. M. (2015) Reversal of a single base pair step controls guanine photo-oxidation by an intercalating Ru(II) dipyridophenazine complex. Angewandte Chemie-International Edition, 54 (29). pp. 8364-8368. ISSN 1433-7851

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To link to this item DOI: 10.1002/anie.201502608

Abstract/Summary

Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo-oxidation by Λ [Ru(TAP)2(dppz)]2+ have been compared in 5′-{CCGGATCCGG}2 and 5′-{CCGGTACCGG}2 using ps/ns transient visible and time-resolved IR (TRIR) spectroscopy. The inefficiency of electron transfer in the TA sequence is consistent with the 5′-TA-3′ vs. 5′-AT-3′ binding preference predicted by X-ray crystallography. The TRIR spectra also reveal the differences in binding sites in the two oligonucleotides.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:40309
Publisher:Wiley VCH
Publisher Statement:This is the peer reviewed version of the following article: 'Reversal of a single base pair step controls guanine photo-oxidation by an intercalating Ru(II) dipyridophenazine complex' which has been published in final form at DOI:10.1002/anie.201502608R2. This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving

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