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From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition

Young, A. M. H., Chakrabarti, B., Roberts, D., Lai, M.-C., Suckling, J. and Baron-Cohen, S. (2016) From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition. Molecular Autism, 7 (1). 9. ISSN 2040-2392

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To link to this item DOI: 10.1186/s13229-016-0068-x

Abstract/Summary

Growing evidence points toward a critical role for early (prenatal) atypical neurodevelopmental processes in the aetiology of autism spectrum condition (ASC). One such process that could impact early neural development is inflammation. We review the evidence for atypical expression of molecular markers in the amniotic fluid, serum, cerebrospinal fluid (CSF), and the brain parenchyma that suggest a role for inflammation in the emergence of ASC. This is complemented with a number of neuroimaging and neuropathological studies describing microglial activation. Implications for treatment are discussed.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Centre for Integrative Neuroscience and Neurodynamics (CINN)
Interdisciplinary centres and themes > ASD (Autism Spectrum Disorders) Research Network
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Neuroscience
Interdisciplinary centres and themes > Centre for Cognition Research (CCR)
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Psychopathology and Affective Neuroscience
ID Code:52480
Publisher:BioMed Central

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