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Cerebellar circuits: biochemistry, neurotransmitters and neuromodulators: cannabinoids as modulators in the cerebellum

Stephens, G. J. (2016) Cerebellar circuits: biochemistry, neurotransmitters and neuromodulators: cannabinoids as modulators in the cerebellum. In: Gruol, D. L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J. D. and Shen, Y. (eds.) Essentials of Cerebellum and Cerebellar Disorders: A Primer For Graduate Students. Springer, Dordrecht, pp. 255-259. ISBN 9783319245492

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To link to this item DOI: 10.1007/978-3-319-24551-5_33

Abstract/Summary

Cannabinoid CB1 receptors (CB1Rs) are the most widespread G-protein-coupled receptors (GPCRs) in the mammalian CNS. CB1Rs are present on inhibitory and excitatory presynaptic terminals supplying Purkinje cells (PCs), the sole output of the cerebellar cortex, where activation suppresses transmitter release. CB1Rs are part of the endocannabinoid (eCB) system, activated by the lipid mediator 2-arachidonoyl glycerol (2-AG) via retrograde transmission. Within the cerebellum, CB1Rs also mediate synaptic plasticities to modulate cerebellar learning. This review will discuss the latest knowledge regarding CB1R circuitry and signalling and their potential modulation.

Item Type:Book or Report Section
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Centre for Integrative Neuroscience and Neurodynamics (CINN)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
ID Code:68703
Publisher:Springer

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