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The effect of dietary lipid manipulation on rat lymphocyte subsets and proliferation

Yaqoob, P., Newsholme, E. and Calder, P. (1994) The effect of dietary lipid manipulation on rat lymphocyte subsets and proliferation. Immunology, 82. pp. 603-610. ISSN 1365-2567

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Abstract/Summary

Polyunsaturated fatty acids (PUFA) have been shown to suppress immune cell functions in vitro. DietarystudiesinvestigatingtheeffectsofPUFA-containingoilson lymphocytefunctionshave yieldedcontradictoryfindings:suchstudiesare difficulttocompare as thereare many variationsin protocols. The present study investigated the effects of diets containing oils rich in saturated fatty acids,monounsaturatedfattyacids,n-6PUFA or n-3PUFA on ratlymphocyteproliferationand on receptorandsurfacemarkerexpression.Ratswere fedfor10weekson a low-fat(LF)diet (approximately2% fatbyweight)or on one offivehigh-fatdiets,whichcontained20% (by weight) hydrogenated coconut oil (HCO), olive oil (00), safflower oil (SO), evening primrose oil (EPO)or menhaden(fish)oil(MO).ComparedwithfeedingtheLF diet,allofthehigh-fatdiets suppressedtheproliferationoflymphocytesfromthespleen:althoughtherewas no significant effectofdieton theproliferationoflymphocytesfromthethymus,therewas a trendtowards decreasedproliferationwithhigh-fatfeeding.Feedingthe00, EPOorMOdietssignificantly suppressed proliferation of mesenteric lymph node lymphocytes compared with feeding the LF, HCO or SO diets.Dietarylipidmanipulationhadno effecton theproportionofT cels,B cellsor monocytes/macrophagesinthespleen,thymusor lymphnodes.Dietarylipidmanipulationalso hadno significanteffecton theproportionsofCD4+ or CD8+ lymphocytesinspleen,thymusor lymphnodes,eitherinfreshlypreparedcellsor incellsculturedinthepresence ofmitogen.There were no significanteffectsofdietarylipidmanipulationon theexpressionofIL-2receptorsor transferrin receptorsbyconcanavalinA (ConA)-stimulatedlymphocytes.However,therewas a trendtowards a decreaseintransferrinreceptorexpressionbyConA-stimulatedlymphocytesfromthethymusand lymphnodesoftheMO-fedratsandtowardsa decreaseintheexpressionofIL-2receptorsby lymphocytes from the spleens and thymi of the MO-fed rats. These observations provide evidence thatsome dietaryoils,particularly00, EPOandMO,possessimmunosuppressivepropertiesand so may beusefulinthetherapyofdiseasesinvolvinginappropriatelymphocyteactivation.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:68774
Publisher:Wiley

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