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Sex: a change in our guidelines to authors to ensure that this is no longer an ignored experimental variable

Docherty, J. R., Stanford, S. C., Panattieri, R. A., Alexander, S. P.H., Cirino, G., George, C. H., Hoyer, D., Izzo, A. A., Ji, Y., Lilley, E., Sobey, C. G., Stanley, P., Stefanska, B., Stephens, G., Teixeira, M. and Ahluwalia, A. (2019) Sex: a change in our guidelines to authors to ensure that this is no longer an ignored experimental variable. British Journal of Pharmacology, 176 (21). pp. 4081-4086. ISSN 0007-1188

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To link to this item DOI: 10.1111/bph.14761

Abstract/Summary

Summary • BJP now requires sex to be considered as an experimental variable for all experimental reporting. This will affect the details of the experimental design that are documented or, in the absence of a design incorporating both sexes, a full justification for that approach. • We recommend that all experiments (in vitro, in vivo, and ex vivo) should include both sexes, unless there is a specific justification or exemption, such as when using immortalised cell lines or tissue derived from a sex organ. • Multifactorial designs should be used to study the overall effects of Sex, Treatment (i.e., the experimental intervention), and their interaction. • Authors should consider the implications for the study findings when testing males and females in close proximity, particularly in behavioural studies, and describe these implications in the discus- sion of the manuscript.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Centre for Integrative Neuroscience and Neurodynamics (CINN)
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
ID Code:90416
Publisher:Wiley

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