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The influence of loops on the binding of the [Ru(phen)2dppz]2+ light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy

Baptista, F. R., Devereux, S. J., Gurung, S. P., Hall, J. P., Sazanovich, I. V., Towrie, M., Cardin, C. J., Brazier, J. A., Kelly, J. M. and Quinn, S. J. (2020) The influence of loops on the binding of the [Ru(phen)2dppz]2+ light-switch compound to i-motif DNA structures revealed by time-resolved spectroscopy. Chemical Communications, 56 (67). pp. 9703-9706. ISSN 1359-7345

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To link to this item DOI: 10.1039/D0CC03702H

Abstract/Summary

Ultrafast time resolved infrared (TRIR) is used to report on the binding site of the [Ru(phen)2(dppz)]2+ 1 “light-switch” complex to i-motif structures in solution. Detailed information is provided due to perturbation of the local base vibrations by a ‘Stark-like’ effect which is used to establish the contribution of thymine base loop interactions to the binding site of 1 in this increasingly relevant DNA structure.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Faculty of Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group
ID Code:91847
Publisher:The Royal Society of Chemistry

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