Accessibility navigation


Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

Trakoshis, S., Martínez-Cañada, P., Rocchi, F., Canella, C., You, W., Chakrabarti, B. ORCID: https://orcid.org/0000-0002-6649-7895, Ruigrok, A. N., Bullmore, E. T., Suckling, J., Markicevic, M., Zerbi, V. ORCID: https://orcid.org/0000-0001-7984-9565, MRC AIMS Consortium, , Baron-Cohen, S., Gozzi, A., Meng-Chuan, L., Panzeri, S. and Lombardo, M. V. (2020) Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women. eLIFE, 9. ISSN 2050-084X

[img]
Preview
Text (Open Access) - Published Version
· Available under License Creative Commons Attribution.
· Please see our End User Agreement before downloading.

3MB

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.7554/eLife.55684

Abstract/Summary

Excitation-inhibition (E:I) imbalance is theorized as an important pathophysiological mechanism in autism. Autism affects males more frequently than females and sex-related mechanisms (e.g., X-linked genes, androgen hormones) can influence E:I balance. This suggests that E:I imbalance may affect autism differently in males versus females. With a combination of in-silico modeling and in-vivo chemogenetic manipulations in mice, we first show that a time-series metric estimated from fMRI BOLD signal, the Hurst exponent (H), can be an index for underlying change in the synaptic E:I ratio. In autism we find that H is reduced, indicating increased excitation, in the medial prefrontal cortex (MPFC) of autistic males but not females. Increasingly intact MPFC H is also associated with heightened ability to behaviorally camouflage social-communicative difficulties, but only in autistic females. This work suggests that H in BOLD can index synaptic E:I ratio and that E:I imbalance affects autistic males and females differently.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Centre for Integrative Neuroscience and Neurodynamics (CINN)
Interdisciplinary centres and themes > ASD (Autism Spectrum Disorders) Research Network
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Neuroscience
Interdisciplinary centres and themes > Centre for Cognition Research (CCR)
Faculty of Life Sciences > School of Psychology and Clinical Language Sciences > Psychopathology and Affective Neuroscience
ID Code:92110
Publisher:eLife Sciences Publications

Downloads

Downloads per month over past year

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation