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Impact of maternal dietary carbohydrate intake and vitamin D-related genetic risk score on birth length: the Vitamin D Pregnant Mother (VDPM) cohort study

Arif Sabta, A., Nur Indrawaty, L., Yusrawati, Y., Safarina G., M., Nur Aini, K., Isman, S., Siti, N., Ratih Devi, A., Wahyuningsih, W., Nur Mukhlishoh, M. and Vimaleswaran, K. S. ORCID: (2022) Impact of maternal dietary carbohydrate intake and vitamin D-related genetic risk score on birth length: the Vitamin D Pregnant Mother (VDPM) cohort study. BMC Pregnancy and Childbirth, 22 (1). 690. ISSN 1471-2393

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To link to this item DOI: 10.1186/s12884-022-05020-3


Background: Our objectives were to investigate the relationship between maternal vitamin D status and IGF-1 levels in healthy Minangkabau pregnant mothers and their impact on newborn anthropometry outcomes and to examine whether this relationship was modified by dietary intake using a nutrigenetic approach. Methods: Healthy singleton pregnant mother and infant pairs (n=183) were recruited. We created three genetic risk scores (GRSs): a six-SNP GRS based on six vitamin D-related single nucleotide polymorphisms (SNPs) involved in the synthesis of vitamin D (vitamin D-GRS), a two-SNP GRS using SNPs in VDR genes (VDR-GRS) and a four-SNP GRS using SNPs from DHCR7, GC, CYP24A1 and CYP2R1 genes (non-VDR GRS). The effect of the GRSs on IGF-1, vitamin D and newborn anthropometry and the interaction between the GRSs and dietary factors were tested using linear regression analysis. Results: The vitamin D- and non-VDR GRSs were significantly associated with lower 25(OH)D concentration (p=0.005 and p=0.001, respectively); however, there was no significant association with IGF-1, and newborn anthropometry outcomes. However, there was a significant interaction of VDR-GRS with carbohydrate intake on birth length outcome (Pinteraction=0.032). Pregnant mothers who had higher carbohydrate intake (405.88 ± 57.16 g/day) and who carried ≥2 risk alleles of VDR-GRS gave birth to babies with significantly lower birth lengths compared to babies born to mothers with <2 risk alleles (p=0.008). Conclusion: This study identified a novel interaction between VDR-GRS and carbohydrate intake on birth length outcome. These findings suggest that reducing the intake of carbohydrates during pregnancy, particularly for those who have a higher genetic susceptibility, might be an effective approach for preventing foetal growth abnormalities.

Item Type:Article
Divisions:Interdisciplinary Research Centres (IDRCs) > Institute for Food, Nutrition and Health (IFNH)
Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
ID Code:107055
Publisher:BioMed Central


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