The potential role of human milk oligosaccharides in irritable bowel syndromeSanz Morales, P., Wijeyesekera, A. ORCID: https://orcid.org/0000-0001-6151-5065, Robertson, M. D., Jackson, P. P. J. and Gibson, G. R. ORCID: https://orcid.org/0000-0002-0566-0476 (2022) The potential role of human milk oligosaccharides in irritable bowel syndrome. Microorganisms, 10 (12). 2338. ISSN 2076-2607
It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.3390/microorganisms10122338 Abstract/SummaryIrritable Bowel Syndrome (IBS) is the most common gastrointestinal (GI) disorder in Western populations and therefore a major public health/economic concern. However, despite extensive research, psychological and physiological factors that contribute to the aetiology of IBS remain poorly understood. Consequently, clinical management of IBS is reduced to symptom management through various suboptimal options. Recent evidence has suggested human milk oligosaccharides (HMOs) as a potential therapeutic option for IBS. Here, we review literature concerning the role of HMOs in IBS, including data from intervention and in vitro trials. HMO supplementation shows promising results in altering the gut microbiota and improving IBS symptoms, for instance by stimulating bifidobacteria. Further research in adults is required into HMO mechanisms, to confirm the preliminary results available to date and recommendations of HMO use in IBS.
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