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The potential role of human milk oligosaccharides in irritable bowel syndrome

Sanz Morales, P., Wijeyesekera, A. ORCID:, Robertson, M. D., Jackson, P. P. J. and Gibson, G. R. (2022) The potential role of human milk oligosaccharides in irritable bowel syndrome. Microorganisms, 10 (12). 2338. ISSN 2076-2607

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To link to this item DOI: 10.3390/microorganisms10122338


Irritable Bowel Syndrome (IBS) is the most common gastrointestinal (GI) disorder in Western populations and therefore a major public health/economic concern. However, despite extensive research, psychological and physiological factors that contribute to the aetiology of IBS remain poorly understood. Consequently, clinical management of IBS is reduced to symptom management through various suboptimal options. Recent evidence has suggested human milk oligosaccharides (HMOs) as a potential therapeutic option for IBS. Here, we review literature concerning the role of HMOs in IBS, including data from intervention and in vitro trials. HMO supplementation shows promising results in altering the gut microbiota and improving IBS symptoms, for instance by stimulating bifidobacteria. Further research in adults is required into HMO mechanisms, to confirm the preliminary results available to date and recommendations of HMO use in IBS.

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Food Microbial Sciences Research Group
ID Code:109361


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