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Fatty acids and immune function: new insights into mechanisms

Yaqoob, P. ORCID: and Calder, P.C. (2007) Fatty acids and immune function: new insights into mechanisms. British Journal of Nutrition, 98 (Supplement). S41-S45. ISSN 0007-1145

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To link to this item DOI: 10.1017/S0007114507832995


Fatty acids are known to play diverse roles in immune cells. They are important as a source of energy, as structural components of cell membranes, as signaling molecules and as precursors for the synthesis of eicosanoids and similar mediators. Recent research has suggested that the localization and organisation of fatty acids into distinct cellular pools has a direct influence on the behaviour of a number of proteins involved in immune cell activation, including those associated with T cell responses, antigen presentation and fatty acid-derived inflammatory mediator production. This article reviews these studies and places them in the context of existing literature in the field. These studies indicate the existence of several novel mechanisms by which altered fatty acid availability can modulate immune responses and impact upon clinical outcomes

Item Type:Article
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences
Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
ID Code:12831
Uncontrolled Keywords:Fatty acid, Fish oil, Omega-3, Eicosanoid, Lipid raft, T cell, Lymphocyte, Antigen presentation, Lipid body, Inflammation
Additional Information:1st International Immunonutrition Workshop Valencia, Spain 2007

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