In vitro antioxidant activity and antigenotoxicity of 5-n-alkylresorcinolsParikka, K., Rowland, I. R., Welch, R. W. and Wähälä, K. (2006) In vitro antioxidant activity and antigenotoxicity of 5-n-alkylresorcinols. Journal of Agricultural and Food Chemistry, 54 (5). pp. 1646-1650. ISSN 0021-8561 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1021/jf052486e Abstract/SummaryIncubation with 5-n-alkylresorcinols (chain lengths C15:0, C17:0, C19:0, C21:0, and C23:0) increased the self-protection capacity of HT29 human colon cancer cells against DNA damage induced by hydrogen peroxide and genotoxic fecal water samples using comet assay (single-cell gel electrophoresis assay). The alkylresorcinols did not exert potent antioxidant activity in the FRAP (ferric reduction ability of plasma) and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical assays. However they were able to significantly inhibit copper-mediated oxidation of human LDL (low-density lipoprotein) in vitro, and pentadecylresorcinol at 25 micromol/L increased lag time by 65 min. The results show that alkylresorcinols have antigenotoxic and antioxidant activity under in vitro conditions.
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