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Bonjoch, J., Drew, M. G.B., Gonzalez, A., Greco, F., Jawaid, S., Osborn, H. M. I. 
ORCID: https://orcid.org/0000-0002-0683-0457, Williams, N. A.O. and Yaqoob, P. ORCID: https://orcid.org/0000-0002-6716-7599
(2008)
Synthesis and evaluation of novel boron-containing complexes of potential use for the selective treatment of malignant melanoma.
Journal of Medicinal Chemistry, 51 (20).
pp. 6604-6608.
ISSN 0022-2623
Full text not archived in this repository.
It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.
To link to this item DOI: 10.1021/jm8007745
Abstract/Summary
Boron-containing complexes that have the potential to irreversibly accumulate in melanoma cells have been prepared by reaction of amino acids with 9-methoxy-9-borabicyclo[3.3.1]nonane. The ability of each complex to act as a substrate for tyrosinase has been probed by oximetry. Increased uptake of the lead candidate in a tyrosinase-rich cell line, compared with a tyrosinase-absent cell line, is reported, with results correlating well with that for a drug currently approved for BNCT.
| Item Type: | Article |
|---|---|
| Refereed: | Yes |
| Divisions: | Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group |
| ID Code: | 4449 |
| Uncontrolled Keywords: | neutron-capture therapy; drug-delivery; l-cysteine; mdept; candidates; prodrugs |
| Publisher: | American Chemical Society |
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