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Potent anthelmintic activity of galloylated proanthocyanidins from shea meal (Vitellaria paradoxa)

Ramsay, A., Williams, A., Quijada, J., Hoste, H., Thamsborg, S. and Mueller-Harvey, I. (2015) Potent anthelmintic activity of galloylated proanthocyanidins from shea meal (Vitellaria paradoxa). Planta Medica, 81 (16). PW_57. ISSN 1439-0221 (Paper from the 63rd International Congress and Annual Meeting of the Society, GA 2015, Budapest)

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To link to this item DOI: 10.1055/s-0035-1565681


Proanthocyanindins (PAs) from shea meal (SM), a by-product obtained after lipid extraction of the nuts, contained B-type linkages, had a high ratio of prodelphinidins (73%) and were galloylated (42%). The average polymer size was 8 flavan-3-ol subunits (≈2384 Daltons) and epigallocatechin gallate was the major subunit. Purified PA fractions from SM were tested in vitro for anthelmintic properties against gastrointestinal nematodes from ruminants (H. contortus and T. colubriformis) [1] by the larval exsheathment inhibition assay and from pigs (A. suum) by the larval migration inhibition assay. Results showed that PAs from SM have a potent anthelmintic activity against those parasites similar to white clover (Trifolium repens) flowers (WCF) [1, 2] (EC50 µg/mL; SM: 55.1, 16.5, 75.9; WCF: 37.4, 14.5, 110.1 for A. suum, H. contortus and T. colubriformis respectively). WCF PAs are constituted almost exclusively of prodelphinidin (PD) compared to SM (98% vs. 73%) but do not contained galloylated PAs. Studies [1, 2] have shown that anthelmintic activity of PAs was mainly associated with their PD ratio but our current results suggest that galloylation can be a major factor to anthelmintic activity and SM as a potential nutraceutical anthelmintic feed for controlling parasitic nematodes.

Item Type:Article
Divisions:Life Sciences > School of Agriculture, Policy and Development > Department of Animal Sciences > Animal, Dairy and Food Chain Sciences (ADFCS)- DO NOT USE
ID Code:52192
Publisher:Thieme Medical Publishers, Inc.

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